Donath-Landsteiner test

Donath-Landsteiner test

 [do´nath land´sti-ner]
a test for paroxysmal hemoglobinuria based on the fact that the blood of patients with this disease contains isohemolysin and autohemolysin that unites with erythrocytes only at low temperatures (2° to 10°C), hemolysis occurring only after warming with the complement to 37°C.
References in periodicals archive ?
A Donath-Landsteiner test can be used to detect the presence of the implicated biphasic hemolysin.
1) In most cases plasma is sufficient, except, for example, in some adsorption studies and would be necessary in testing that required complement such as the Donath-Landsteiner test.
The unique biphasic nature of this condition can be demonstrated in vitro using the Donath-Landsteiner test.