It is notable that methadone is the second most frequent cause of drug arrhythmia after dofetilide
(Kao et al.
The launch of doxycycline hyclate IR tablets is Mayne Pharma's fourth first-to-market generic launch since June last year after dofetilide
capsules, butalbital acetaminophen tablets (50 mg/300 mg) and methylphenidate extended-release capsules f60 mg).
The use of these drugs (such as propafenone, dofetilide
, and amiodarone) has been limited by proarrhythmic and noncardiovascular toxicities as well as modest antiarrhythmic efficacy.
5 mg/hr for 18 hr Dofetilide
Oral: 125 to 500 meg q12 hr 125-500 meg q 12 hr.
received approval from the FDA to market dofetilide
capsules, a generic alternative to Tikosyn, an anti-arrhythmic agent used to treat irregular heartbeats, such as atrial fibrillation and atrial flutter.
For patients who achieve sinus rhythm, there are several choices of antiarrhythmic agent to be considered for a rhythm-control strategy, including amiodarone, dofetilide
, dronedarone, flecainide, propafenone, and sotalol.
Drug Interactions: Co-administration of cisapride, pimozide, quinidine, dofetilide
, levacetylmethadol (levomethadyl), felodipine, oral midazolam, nisoldipine, triazolam, lovastatin, simvastatin, ergot alkaloids such as dihydroergotamine, ergometrine (ergonovine), ergotamine and methylergometrine (methylergonovine) or methadone with ONMEL[TM] is contraindicated.
Until relatively recently, the only method of choice has been antiarrhythmic medications: amiodarone (Cordarone, Pacerone), dofetilide
(Tikosyn), dronedarone (Multaq), flecainide (Tambocor), propafenone (Rhythmol), and sotalol (Betapace).
Table 1--Causes of Long QT Syndrome Congenital Acquired Inherited Metabolic chairnelopathies Roman o-Ward Hypocalcernia, Syndrome hypokalemia, hypomagnesemia Jervell and Lange-Nielsen Syndrome Idiopathic Anti-Arrytbmics Amiodarone, Diospyramide, Dofetilide
, ibutilide, Quinidine, Procainamide, Sotalol Antibistarnines Asteinizole, Terfenidine Anti-Infectives Clan thromycin, Erythrornycin, Pentamidine, Sparfi oxcin Anti-Malarial Chioroquine, Halofantrinc Psychotropics Chiorprornazine, Flaloperidol, Thioridazone, SSRIs Heart Disease Left ventricular hvpertrop hy, heart failure, invocardial isehemia
4) Rate control was achieved with beta-blockers with or without digitalis, and rhythm control was maintained by cardioversion, amiodarone, sotalol, or dofetilide
The newer antiarrhythmics like dofetilide
and ibutilide are more potent as well as highly selective for [K.
in patients with congestive heart failure and left ventricular dysfunction.