, as the evidence to show clear benefit in improving chronic constipation in older adults is lacking.
Robinson, "Psyllium is superior to docusate
sodium for treatment of chronic constipation," Alimentary Pharmacology and Therapeutics, vol.
Discharge medications included the following: quetiapine 100 mg in the morning and 600 mg every bedtime, venlafaxine 187.5 mg daily, to be increased to 225 mg daily two days after discharge, melatonin 3 mg every bedtime, ranitidine 300 mg daily, vitamin D 1000 IU daily, brimonidine-timolol drops, brinzolamide drops, budesonide spray, docusate
sodium, and lactulose.
For example, docusate
sodium is a detergent and, while it was recently shown to activate PPAR[gamma] (Temkin et al.
Moreover, stool softeners such as docusate
sodium may be used alone or in combination with psyllium husks to increase stool volume and, therefore, peristalsis reflex [6, 7, 125].
He did have a one-week history of constipation for which he was given sodium phosphate enemas, magnesium citrate and docusate
sodium, eventually resulting in a bowel movement.
A safe, over-the-counter (OTC), non-addictive pill such as Colace (docusate
) will draw water into the stool to make it softer.
His outpatient medications included olanzapine, mirtazapine, trazodone as needed, naproxen, simvastatin, docusate
Changes in laxative medication use for constipation before abdominal massage (AM) and after abdominal massage (AM) at six-week intervention Number of prescriptions Macrogol 21 15 Latulose 3 1 Sodium picosulphate 1 1 Glycerin suppositories 4 1 Bisocodyl 1 0 Docusate
sodium 1 0 Note: Table made from bar graph.
She was prescribed morphine and oxycodone (as needed) for pain; hydroxychloroquine and prednisone for SLE; and mesalamine, docusate
, and infliximab for Crohn disease.
TABLE 2 Common treatments for constipation Bulk-forming laxatives absorb water, increasing fecal mass * psyllium seed (Metamucil) * methylcellulose (Citrucel) * calcium polycarbophil (FiberCon) * wheat Dextran (Benefiber) Surfactant agents lower the surface tension of stool, allowing water to enter the stool * docusate
sodium (Colace) Osmotic laxatives contain poorly/nonabsorbed substances, leading to intestinal water secretion * polyethylene glycol (MiraLAX) * magnesium citrate (Milk of Magnesia) Stimulant laxatives increase colonic transit and alter electrolyte transport across the colonic mucosa * bisacodyl (Dulcolax) * senna (Senokot)
Based on the literature and consensus exert opinion, pediatric physicians agreed to use daily polyethylene glycol for bowel regimen with or without docusate