For detection of hantavirus IgG and IgM, we used an immunofluorescent assay (IFA) with mosaic slides containing SEOV and other orthohantaviruses Puumala virus, Sin Nombre virus, Hantaan virus, Dobrava-Belgrade virus
, and Saaremaa virus (Euroimmun, Lubeck, Germany), according to the manufacturer's instructions (16).
The Profile 1 blot does not contain SEOV antigen, but serum from the patient showed reactivity for Dobrava-Belgrade virus
(DOBV) IgG and HTNV IgM.
Molecular taxonomical analyses identified Sochi virus as a new genotype within the Dobrava-Belgrade virus
(DOBV) species (5).
HFRS in Europe is caused mainly by Puumala virus and different genotypes of Dobrava-Belgrade virus
At least 5 hantavirus species are known to circulate in Europe: Dobrava-Belgrade virus
, Puumala virus (PUUV), Seoul virus, Saarema virus, and Tula virus (TULV).
It has been reported that SEOV causes a milder form of hemorrhagic fever with renal syndrome than Hantaan virus and Dobrava-Belgrade virus
and is responsible for 25% of cases of hemorrhagic fever with renal syndrome in Asia (1).
We identified Dobrava-Belgrade virus
infection in Turkey (from a strain related to hantavirus strains from nearby countries) in a patient who had severe symptoms leading to panhypopituitarism, but no known risk for hantavirus.
(DOBV) is a hantavirus that appears in 3 distinct lineages hosted by different Apodemus species.
In this country, Puumala virus (PUUV) causes most clinical hantavirus cases, although Dobrava-Belgrade virus
and Tula virus also circulate (1).
(DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%.
At least 3 different pathogenic hantavirus species have been detected in Europe: Dobrava-Belgrade virus
(DOBV), Tula virus, and Puumala virus (PUUV) (1-3).
Among the hantaviruses that cause HFRS in Eurasia are Hantaan virus (HTNV), Seoul virus (SEOV), Puumala virus (PUUV), and Dobrava-Belgrade virus
(DOBV) (3), which are carried by the striped field mouse (Apodemus agrarius), Norway rat (Rattus norvegicus) and black rat (R.