HFRS in Europe is caused mainly by Puumala virus and different genotypes of Dobrava-Belgrade virus
At least 5 hantavirus species are known to circulate in Europe: Dobrava-Belgrade virus, Puumala virus (PUUV), Seoul virus, Saarema virus, and Tula virus (TULV).
The causative agents of hemorrhagic fever with renal syndrome in Central Europe are Dobrava-Belgrade virus and PUUV (4).
It has been reported that SEOV causes a milder form of hemorrhagic fever with renal syndrome than Hantaan virus and Dobrava-Belgrade virus
and is responsible for 25% of cases of hemorrhagic fever with renal syndrome in Asia (1).
At least 3 different pathogenic hantavirus species have been detected in Europe: Dobrava-Belgrade virus
(DOBV), Tula virus, and Puumala virus (PUUV) (1-3).
Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%.
Annually, 10,000-12,000 clinical cases of Puumala virus (PUUV) and Dobrava-Belgrade virus (DOBV) infection, mainly characterized by kidney failure, are reported from European Russia.
In this country, Puumala virus (PUUV) causes most clinical hantavirus cases, although Dobrava-Belgrade virus
and Tula virus also circulate (1).
(DOBV) is a hantavirus that appears in 3 distinct lineages hosted by different Apodemus species.
We identified Dobrava-Belgrade virus infection in Turkey (from a strain related to hantavirus strains from nearby countries) in a patient who had severe symptoms leading to panhypopituitarism, but no known risk for hantavirus.
By testing for neutralizing antibodies and by amplification and molecular characterization of virus samples, we identified the causative pathogen as a strain of Dobrava-Belgrade virus (DOBV) that is closely related to a hantavirus strain typically carried by the yellow-necked field mouse (Apodemusflavicollis), strain DOBV-Af.
Among the hantaviruses that cause HFRS in Eurasia are Hantaan virus (HTNV), Seoul virus (SEOV), Puumala virus (PUUV), and Dobrava-Belgrade virus
(DOBV) (3), which are carried by the striped field mouse (Apodemus agrarius), Norway rat (Rattus norvegicus) and black rat (R.