Dobrava Virus

A distinct regional member of the Hantavirus group isolated from a rodent reservoir, the yellow-necked field mouse (Apodemus flavicollis), found in Eastern Europe
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Among the related viruses of the DOBV species, Sochi virus seems to have the highest level of virulence, similar to Dobrava virus (carried by A.
Hantaan virus and its related strains, Seoul virus, Dobrava virus, and Puulmala virus, cause Korean hemorrhagic fever (KHF) in the Far East; hemorrhagic fever with renal syndrome (HFRS), nephrosonephritis, or Tula fever in Russia and China; and nephropathia epidemica (NE) in Scandinavia.
Identification of genetic evidence for Dobrava virus spillover in rodents by nested reverse transcription (RT)-PCR and TaclMan RT-PCR.
First molecular identification of human Dobrava virus infection in central.
Results of hantavirus serologic testing, Ostrava, Czech Republic, October 2012 * Serum samples obtained on day Positivity range (IP) Virus 11 12 20 39 ([dagger]) Hantavirus IgG ELISA 0.26 0.38 2.69# 2.60# >1.1 Hantavirus IgM ELISA 1.17# 3.12# 4.07# 2.78# >1.1 Puumala virus IgG ND Negative ND ND ND Immunoblot Puumala virus IgM ND Positive# ND ND ND Immunoblot Dobrava virus IgG ND Negative ND ND ND Immunoblot Dobrava virus IgM ND Negative ND ND ND Immunoblot Hantaan virus IgG ND Negative ND ND ND Immunoblot Hantaan virus IgM ND Negative ND ND ND Immunoblot * Bold font indicates positive results.
HFRS is caused by the prototypic hantavirus Hantaan and by Dobrava virus, Puumala virus (PUUV), and Seoul virus in Eurasia; HCPS is caused by Andes virus, Sin Nombre virus and related hantaviruses in the Americas.
Puumala virus (PUUV), Dobrava virus (DOBV), and Seoul virus cause different forms of hemorrhagic renal syndrome (1,2).
Isolation of Dobrava virus from Apodemus flavicollis in Greece.
Several lineages of Dobrava virus circulate in Europe and Russia (3-6), and are named according to their rodent reservoirs: Apodemus flavicollis (Dobrava-Af), A.
Characterization of Dobrava virus: a Hantavirus from Slovenia, Yugoslavia.
Thirty cases of hemorrhagic fever with renal syndrome (HFRS) due to Puumala virus (PUUV), Saaremaa virus (SAAV), and Dobrava virus infection were confirmed in Estonia.
Designated Cao Bang virus (CBNV), the newly identified hantavirus exhibited low nucleotide and amino acid sequence similarity to representative hantaviruses harbored by Murinae, Arvicolinae, Neotominae, and Sigmodontinae rodents, ranging from 62.6% (nt) and 61.2% (aa) for Hantaan virus (HTNV) 76-118; 62.3% (nt) and 61.7% (aa) for Dobrava virus (DOBV) Greece to 58.1% (nt) and 52.0% (aa) for Puumala virus Sotkamo; and 58.8% (nt) and 54.7% (aa) for Sin Nombre virus NMH10 (Table 2).