DNA polymerase(redirected from Dna polymerase beta)
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Enzymes that catalyze the transfer of transferring nucleotide residues (nucleotidyls) from nucleoside di- or triphosphates into dimer or polymer forms. Some nucleotidyltransferases bear specific names (for example, adenylyltransferases), trivial names indicating the linkage hydrolyzed in the synthesis (pyrophosphorylases, phosphorylases), or names indicating the material that is synthesized (for example, RNA or DNA polymerase).
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Any of various enzymes that function in the replication and repair of DNA by catalyzing the linking of dATP, dCTP, dGTP, and dTTP in a specific order, using single-stranded DNA as a template.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
DNA polymerasea group of enzymes that are responsible for the polymerization of free NUCLEOTIDES on to the unwound DNA molecule during DNA REPLICATION. The first DNA polymerase was discovered by A. Kornberg in 1957 (for which work he received the Nobel Prize). There are several polymerases in any organism. For example, in E. coli, DNA polymerase III synthesizes both the leading and the lagging strands (see DNA, REPLICATION); DNA polymerase I fills in the gaps between Okazaki fragments. In EUKARYOTES, three DNA polymerases are involved in chromosome replication: polymerase α, δ and ɛ; mitochondrial DNA synthesis involves polymerase γ. Most DNA polymerases also have an EDITING function.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005