disintegrins

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disintegrins

A family of snake venom anticoagulants that bind to INTEGRINS on the surface of platelets and cells, preventing their interaction with the extracellular matrix and with other cells. They inhibit tumour growth and angiogenesis and may have value in the treatment of cancer.
References in periodicals archive ?
It encodes the membrane-anchored enzyme disintegrin and metalloproteinase domain-containing protein 33, which influences the activity of growth factors and cytokines that are involved in the remodeling of airways.
A study11 hypothesised that the alteration of the amino-terminal glycosylation (N-glycosylation) state of the protein, caused by the Gly82Ser polymorphism, induces structural changes in the protein that makes RAGE more vulnerable for the action of proteinases, such as a disintegrin and metalloproteinases 10 and matrix metalloproteinase-9, and affects the binding of antibody (in ELISA kits obtained from RandD Systems) to esRAGE ultimately affecting our immunoassay.
The striking features of micropapillary UC were downregulation of miR-296, with overexpression of its nearly 300 target genes and activation of chromatin-remodeling complex RuvB-like 1 (RUVBL1) with overexpression of its downstream target genes such as lysine-specific demethylase 4B (KDM4B), insulin-like growth factor-binding protein 3 (IGFBP3), and disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) involved in cell growth, DNA damage repair, and metastasis.
Thrombotic microangiopathy (TMA) is usually hereditary and due to acquired causes that lead to severe a disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13) deficiency.
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) plays a key role in the pathogenesis of TTP.
The breakdown of AGC is believed to be initiated by a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and ADAMTS-5.[1]
Enzymes associated with membrane RANKL cleavage, such as membrane type-1 (MT1)-MMP, ADAM17, and ADAM19 (a disintegrin and metalloproteinase domain 17 and 19), did not have their expression altered in the cultures with SrRan (26).
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are secreted, extracellular enzymes with a compound domain organization [1].
Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopeniaassociated multiple organ failure.
Matrix metalloproteinases (MPP-LP, CGI_10025346), disintegrin, and metalloprotease (ADAM-LP, CGI_10027133) have low expression levels throughout oyster development.
(11) did not recommend performing of measurements that have not been proven to be definitely associated with thrombosis including homocysteine, MTHFR, tissue factor pathway inhibitor, coagulation factor level, lipoprotein (a), thrombomodulin, endothelial protein C receptor, angiotensin converting enzyme, protein Z and protein Z-dependent protease inhibitor, and disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS13) in these patients.
Zerillo et al., "Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member," The Journal of Biological Chemistry, vol.

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