ganglioside

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ganglioside

 [gang´gle-o-sīd]
a class of galactose-containing cerebrosides found in central nervous system tissues; they are glycolipids of the basic composition ceramide-glucose-galactose-N-acetyl neuraminic acid. The form GM1 accumulates in tissues in generalized gangliosidosis, the form GM2 in Tay-Sachs disease.

gan·gli·o·side

(gang'glē-ō-sīd),
A glycosphingolipid chemically similar to cerebrosides but containing one or more sialic (N-acetylneuraminic or N-glycolylneuraminic) acid residues; found principally in nerve tissue, spleen, and thymus; ganglioside GM1 accumulates in generalized gangliosidosis; GM2 accumulates in Tay-Sachs disease.

ganglioside

(găng′glē-ə-sīd′)
n.
Any of a group of galactose-containing cerebrosides found in the surface membranes of nerve cells.

gan·gli·o·side

(gang'glē-ō-sīd)
Glycosphingolipid chemically similar to cerebrosides but containing one or more sialic acid residues; found principally in nerve tissue, spleen, and thymus; GM1 accumulates in generalized gangliosidosis; GM2 accumulates in Tay-Sachs disease.

ganglioside

A compound of fat and carbohydrate (glycolipid) that is an important component in cell membranes.

Ganglioside

A fatty (lipid) substance found within the brain and nerve cells.
Mentioned in: Tay-Sachs Disease
References in periodicals archive ?
Rosenblum, "A potent and specific immunotoxin for tumor cells expressing disialoganglioside GD2," Cancer Immunology, Immunotherapy, vol.
Lin et al., "Single-chain Fvstreptavidin substantially improved therapeutic index in multistep targeting directed at disialoganglioside GD2," Journal of Nuclear Medicine, vol.
Cheung, "Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors," OncoImmunology, vol.
Brennan, "Expression of disialogangliosides [G.sub.D2] and [G.sub.D3] on human soft tissue sarcomas," Cancer, vol.
Reisfeld, "Biosynthesis and expression of the disialoganglioside GD2, a relevant target antigen on small cell lung carcinoma for monoclonal antibody-mediated cytolysis," Cancer Research, vol.
Reisfeld, "Disialoganglioside GD2 on human neuroblastoma cells: target antigen for monoclonal antibody-mediated cytolysis and suppression of tumor growth," Cancer Research, vol.
Scarsdale et al., "Characterization of a hamster melanoma-associated ganglioside antigen as 7-Oacetylated disialoganglioside GD3," Journal of Lipid Research, vol.
Five sphingoglycolipids have pyruvic acid and their acidity may be comparable to monosialo-or disialogangliosides.