DPP4

(redirected from Dipeptidyl peptidase 4)

DPP4

A gene on chromosome 2q24.3 that encodes dipeptidyl-peptidase 4, a ubiquitous, membrane-bound enzyme with roles in nutrition, metabolism, the endocrine system, immune regulation (for instance, it is essential for T-cell receptor (TCR)-mediated T-cell activation), bone marrow mobilisation, apoptosis, cell adhesion and tumourigenesis.
References in periodicals archive ?
The team from Kolkata's CSIR-Indian Institute of Chemical Biology, Republic of Korea's Institute for Basic Science (IBS), Kolkata's Vidyasagar College and the Institute of Postgraduate Medical Education and Research (IPGMER) here has in a recent study answered a long standing question as to why diabetics have more amount of an enzyme called dipeptidyl peptidase 4 or DPP4 in their blood.
Though the manufacturer announced the main cardiovascular findings on sitagliptin (Januvia), earlier this year, the details of this trial--driven by concerns about a signal for increased risk of heart failure in two earlier trials of dipeptidyl peptidase 4 (DPP-4) inhibitors--were presented for the first time.
Inhibition of dipeptidyl peptidase 4 by BI-1356, a new drug for the treatment of beta-cell failure in type 2 diabetes.
The dipeptidyl peptidase 4 (DPP-4) inhibitor, in a single 5-mg tablet formulation, is indicated for improving blood glucose control in adults with type 2 diabetes in combination with diet and exercise.
Boehringer Ingelheim Pharmaceuticals is investigating the dipeptidyl peptidase 4 (DPP-4) inhibitor linagliptin as an oral once-daily tablet, as monotherapy and combination therapy, to treat T2D.
Both compounds inhibit an enzyme called dipeptidyl peptidase 4 (DPP-4), which usually controls the body's production of a hormone, called GLP1.

Full browser ?