Dioctyl


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docusate calcium

Apo-Docusate Calcium (CA), Calax (CA), DC Softgels, Novo-Docusate Calcium (CA), PMS-Docusate Calcium (CA), Ratio-Docusate Calcium (CA), Soflax C (CA), Stool Softener DC, Surfak Liquigels

docusate sodium

Apo-Docusate Sodium (CA), Colace, Correctol, Correctol Stool Softener (CA), Diocto, Dioctyl (UK), Docusol (UK), Dom-Docusate Sodium (CA), D.O.S. Softgels, Docu-Soft, DOK, D-S-S, DulcoEase (UK), Dulcolax Stool Softener, Enemeez, Genasoft Softgels, Norgalax (UK), Novo Docusate (CA), PHL-Docusate Sodium (CA), PMS-Docusate Sodium, Ratio-Docusate Sodium (CA), Selax (CA), Silace

Pharmacologic class: Emollient

Therapeutic class: Stool softener, surfactant

Pregnancy risk category C

Action

Increases absorption of liquid into stool, resulting in softening of fecal mass. Also promotes electrolyte and water secretion into colon.

Availability

docusate calcium

Capsules: 240 mg

Capsules (soft gels): 240 mg

Rectal solution: 283 mg/5 ml

docusate sodium

Capsules: 50 mg, 100 mg, 250 mg

Capsules (soft gels): 100 mg, 250 mg

Liquid: 150 mg/15 ml

Syrup: 50 mg/15 ml, 60 mg/15 ml, 20 mg/5 ml, 100 mg/30 ml, 150 mg/15 ml

Tablets: 100 mg

Indications and dosages

Stool softener

Adults and children older than age 12: 240 mg (docusate calcium) or 50 to 200 mg (docusate sodium) P.O. daily until bowel movements are normal

Children ages 6 to 12: 40 to 120 mg (docusate sodium) P.O. daily

Children ages 3 to 6: 20 to 60 mg (docusate sodium) P.O. daily

Contraindications

• Hypersensitivity to drug

• Abdominal pain, nausea, or vomiting

• Intestinal obstruction

Precautions

Use cautiously in:

• pregnant or breastfeeding patients.

Administration

• Give tablets and capsules with full glass of water.

• Give liquid solution with milk or fruit juice.

• Be aware that excessive or long-term use may lead to laxative dependence.

Adverse reactions

EENT: throat irritation

GI: nausea, diarrhea, mild cramps

Skin: rash

Other: bitter taste, decreased appetite, laxative dependence

Interactions

Drug-drug. Mineral oil: increased mineral oil absorption, causing toxicity

Warfarin: decreased warfarin effects (with high doses)

Patient monitoring

• If diarrhea occurs, withhold drug and notify prescriber.

• Know that therapeutic efficacy usually becomes apparent 1 to 3 days after first dose.

Patient teaching

• Instruct patient to drink sufficient fluids with each dose and to increase fluid intake during the day.

• Advise patient to prevent constipation by increasing fluids and consuming more dietary fiber (as in fruits and bran).

• Inform patient that excessive or prolonged use may lead to laxative dependence.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

Dioctyl

A brand name for DOCUSATE SODIUM.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Dioctyl Terephthalate Market Research Report by Product Type (Content 99.5%, Content 99%, Content 98%, Content 96%), by Application (Consumer Goods, Wire & Cable, Film & Sheet, Coated Fabrics, Medical Devices, Automotive Parts, Flooring, Gaskets, Others), and Region - Forecast to 2023
Industry analysis report on Global Dioctyl Maleate Market 2019 by implementing an exquisite analysis procedure to assemble key knowledge of this market.
Zhu et al., "Synthesis of anion polyacrylamide under UV initiation and its application in removing dioctyl phthalate from water through flocculation process," Separation and Purification Technology, vol.
Peak identities are as follows: (1) dibutyl phthalate (DBP); (2) benzyl butyl phthalate (BBP); (3) bis(2-ethylhexyl) adipate (DEHA); (4) bis(2-ethylhexyl) phthalate (DEHP); (5) di-n-octyl phthalate (DNOP); (6) dioctyl terephthalate (DOTP); (7) diisononyl phthalate (DINP); (8) diisodecyl phthalate (DIDP); IS, benzyl benzoate (BB).
These precursors were mixed with 10 mL dioctyl ether under nitrogen atmosphere.
Both dispersants are composed of propylene glycol and organic salts including dioctyl sodium sulfosuccinate (DOSS).
Nelson, "Acute mouse and chronic dog toxicity studies of danthron, dioctyl sodium sulfosuccinate, poloxalkol and combinations," Drug and Chemical Toxicology, vol.
The US EPA listed six PAEs as priority toxic pollutants, including dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), di-2-ethylhexyl phthalate (DEHP), and dioctyl phthalate (DOP), and China also regulated three PAEs (DEP, DMP, and DOP) as environmental priority control pollutants.
Samples of the megalopae were initially taken to an independent laboratory in Pensacola, FL, for analytical testing and the presence of the dispersant compound dioctyl sodium sulfosuccinate and the biomarkers pristane and phytane were identified in the samples using an AccuTOF-DART Mass Spectrometer, JEOL Ltd.
The main components of NBR rubbers and their mass fractions possessed the following qualities: crude rubber 100, ZnO 2.5, stearic acid 2, dioctyl phthalate (DOP) 10, sulfur 1.5, and accelerating agent 2.
Group B was given 0.15 ml of Dioctyl phthalate (DOP) dissolved in 0.4 ml of corn oil daily for 15 days.
The most frequently used as solvent mediators to obtain different sensors are dioctyl phthalate [2-7], nitrobenzene and benzyl acetate [2,7- 16], dibutyl phthalate [5,8-17], nitrophenyloctyl ether [3,11,13,15-20], bis(2-ethylhexyl)sebacate [4,5,20,21].