dimer

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Related to Dimerisation: Dimerization

dimer

 
1. a compound formed by combination of two identical simpler molecules.
2. a capsomer having two structural subunits.
D-dimer a fragment of fibrin that is formed as a result of fibrin degradation. A positive test for its presence in the blood is suggestive of conditions such as thrombotic disease, sickle cell crisis, malignancy, disseminated intravascular coagulation, or recent surgery.

di·mer

(dī'mĕr),
A compound or unit produced by the combination of two like molecules; in the strictest sense, this occurs without the loss of atoms (thus, nitrogen tetroxide, N2O4, is the dimer of nitrogen dioxide, NO2), but usually by elimination of H2O or a similar small molecule between the two (for example, a disaccharide), or by simple noncovalent association (as of two identical protein molecules); higher orders of complexity are called trimers, tetramers, oligomers, and polymers.
[G. di-, two, + -mer]

di·mer

(dī'mĕr)
A compound or unit produced by the combination of two like molecules; in the strictest sense, without loss of atoms (thus nitrogen tetroxide, N2O4, is the dimer of nitrogen dioxide, NO2), but usually by elimination of H2O or a similar small molecule between the two (e.g., a disaccharide), or by simple noncovalent association (as of two identical protein molecules); higher orders of complexity are called trimers, tetramers, oligomers, and polymers.
[G. di-, two, + -mer]

dimer

a molecule made by the joining of two molecules of the same kind, i.e. two MONOMERS. Ultraviolet light can induce THYMINE DIMERS in DNA.
References in periodicals archive ?
LPS and MD-2 (constitutively bound) binding to TLR4 is required for the TLR4 complex dimerisation to take place [27].
TBK1 and IKK[epsilon] are then free to phosphorylate IRF3, which is activated upon phosphorylation and dimerisation and stimulates the production of type I interferons [48, 56].
Folding and dimerisation of tick-borne ancephalitis virus envelope proteins prM and E in the endoplasmic reticulum.
Additionally, CXCR4 is a good example of how regulation of GPCR signalling can be influenced by receptor dimerisation. The formation of heterodimers between wild-type and truncated CXCR4 is thought to account for the increased signalling to CXCL12 activation and their inability to be endocytosed [54].
Our results confirmed the ability of GST to activate other proteins through dimerisation [19, 20].
Edwards, "Dimerisation of maize glutathione transferases in recombinant bacteria" Plant Molecular Biology, vol.
These preclinical data support the company's conviction that an Anticalin, which is monomeric by nature, is particularly suited for antagonising a receptor activated through dimerisation such as c-Met, said Stephen Yoder, CEO of Pieris.
A number of different approaches to targeting survivin are being explored, including molecular antagonists against survivin mRNA to inhibit translation, dominant negative mutants to prevent dimerisation, small-molecule antagonists to block phosphorylation and immunotherapy [16] (see Figure 3).
Pertuzumab is a humanised monoclonal antibody that binds to HER2 and inhibits the dimerisation of HER2 with other members of the HER family, thus inhibiting cell survival pathways important in neoplastic transformation and progression [16].
The potential dimerisation partners determine in part the variable downstream functions of HER2 signalling--with HER2:HER3 being the most potent combination to stimulate downstream pathways [1].