Natarajan, 1,3- Diketones from Acid Chlorides and Ketones: A Rapid and General One-Pot Synthesis of Pyrazoles, Org.
Kewords: Diphenyl methane, Diketone, Hydrazide, Pyrazole, Solvent free.
Morgan's findings provide strong evidence that inhaled diketone vapors can produce airway fibrotic disease and support a causal relationship between workplace exposure to high concentrations of diketones and the development of bronchiolitis obliterans, according to John Morris, a professor of pharmacology and toxicology at the University of Connecticut, Storrs.
Caption: Engineering controls such as ventilated mixing vessels with hinged lids or access ports are the first line of protection against worker exposures to diketones in flavorings.
During the wort fermentation period, several reactions closely related to cytoplasmic membrane occur in yeast, among them are: nutrients uptake, metabolic by-products extrusion, respiratory activity, vicinal diketones reduction, etc.
The vicinal diketones (VDKs), diacetyl and pentanedione, are secondary by-products of the biosynthetic pathway for valine and isoleucine, respectively.
For example, oxygen-donor ligands include ater, hydroxide, and oxide; dioxygen, superoxide, and peroxide; alkoxides and aryl oxides; diketones
; oxyanions; carboxylates; hydroxy acids; sulfoxides, amides, and amine oxides; and hydroxamates.
CS 8 is concerned with the "popcorn lung", i.e., respiratory effects of diketones
; for this case study the compound selection is completed and agreed on as well as the methods and the testing protocols.
The samples of PVOH exposed to the Phanerochaete chrysosporium enzymes during 5 days showed deterioration, which implies changes in the chemical structures (oxidation or loss of small fragments) since in the UV signals show the possible formation of enolized [Beta] diketones. FTIR confirms this assignment and also shows transformation of the C-O bonds.
This can be associated with modifications in the chemical environment of the carbonyl bonds and also to a possible formation of [Beta] enolized diketone groups.
A MA model product with the diketone structure but without curable group was also synthesized for the mechanistic study.
It was inferred that the substituted [beta]-diketone underwent photolysis during exposure and the diketone structure was broken down.