(DFP) reduces serum prolactin, thyrotropin, luteinizing hormone, and growth hormone and increases adrenocorticotropin and corticosterone in rats: involvement of dopaminergic and somatostatinergic as well as cholinergic pathways.
Regarding mechanisms, diisopropylfluorophosphate
(an acetylcholinesterase inhibitor like organophosphates and carbamates) has been shown to suppress TSH production potentially via pathways involving muscarinic and nicotinic receptors (Smallridge et al.
25K-FPR1 Sensitivity to Diisopropylfluorophosphate
Treatment of PMN.
Therefore, we prepared trypsin derivatives inactivated with active-site directed modification reagents such as DFP (diisopropylfluorophosphate
) or TLCK (tosyl-L-lysine chloromethylketone).
Bartlett, "Determination of diisopropylfluorophosphate
in rat plasma and brain tissue by headspace solid-phase microextraction gas chromatography/mass spectrometry," Rapid Communications in Mass Spectrometry, vol.
funiculosum have pH optima at 5.5 or 6.0, respectively, and (v) most of them are inhibited by serine hydrolase inhibitors such as diisopropylfluorophosphate
or acylsulfonyl compounds, which bind covalently to the active site of serine hydrolases .
Russia argues that the substances are well-known to specialists: diisopropylfluorophosphate
(DFP) and sarin, which were not synthesized industrially.