isoflurophate

(redirected from Diisopropylfluorophosphate)
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isoflurophate

(ī-sō-floo′rō-fāt)
An anticholinesterase drug used in treating glaucoma as well as atony of the smooth muscle of the intestinal tract and urinary bladder.
References in periodicals archive ?
Diisopropylfluorophosphate (DFP) reduces serum prolactin, thyrotropin, luteinizing hormone, and growth hormone and increases adrenocorticotropin and corticosterone in rats: involvement of dopaminergic and somatostatinergic as well as cholinergic pathways.
Regarding mechanisms, diisopropylfluorophosphate (an acetylcholinesterase inhibitor like organophosphates and carbamates) has been shown to suppress TSH production potentially via pathways involving muscarinic and nicotinic receptors (Smallridge et al.
Therefore, we prepared trypsin derivatives inactivated with active-site directed modification reagents such as DFP (diisopropylfluorophosphate) or TLCK (tosyl-L-lysine chloromethylketone).
Bartlett, "Determination of diisopropylfluorophosphate in rat plasma and brain tissue by headspace solid-phase microextraction gas chromatography/mass spectrometry," Rapid Communications in Mass Spectrometry, vol.
funiculosum have pH optima at 5.5 or 6.0, respectively, and (v) most of them are inhibited by serine hydrolase inhibitors such as diisopropylfluorophosphate or acylsulfonyl compounds, which bind covalently to the active site of serine hydrolases [3].
Russia argues that the substances are well-known to specialists: diisopropylfluorophosphate (DFP) and sarin, which were not synthesized industrially.