Sulfonamides inhibit dihydropteroate
synthase just like 4-aminobenzoic acid due to structural similarities.
Interhuman transmission as a potential key parameter for geographical variation in the prevalence of Pneumocystis jirovecii dihydropteroate
Pyrimethamine and sulfadoxine can inhibit dihydrofolate reductase (DHFR) and dihydropteroate
synthase (DHPS) enzymes.
Resistance to sulphadoxine and sulfa drugs arise from the accumulation of mutations at five codons in the dihydropteroate
synthase (dhps) gene leading to amino acid change S436A, A437G, K540E, A581G, and S436F .
However, the mutations in folP [encoding the sulfonamide target the enzyme dihydropteroate
synthase (DHPS)] are linked to sulphonamide resistance and the mtrR mutations or erm genes to macrolides resistance .
DNA extraction and PCR amplification of Pneumocystis jirovecii dihydropteroate
[Gene polymorphisms in the dihydrofolate reductase (dhfr) and dihydropteroate
synthase (dhps) genes and structural modelling of the dhps gene in Colombian isolates of Toxoplasma gondii [in Spanish].
sulfanilamides are considered inhibitors of dihydropteroate
Sull is dihydropteroate
synthase which has almost exclusively been found on large conjugative plasmids and on class 1 integrons .
Potent drugs are required to treat certain organisms which are resistant to approved anti-biotic, therefore, there is always an overwhelming need for synthesis of new and effective anti-bacterial agents for the treatment of infections caused by antibiotic resistant pathogenic bacteria by targeting on enzyme; dihydropteroate
synthase, which catalyze folic acid synthesis in bacteria and eukaryotes but not in humans.
Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihyrofolate reductase (DHFR) and dihydropteroate
synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy.
synthase of Mycobacterium leprae and dapsone resistance.