dihydropteroic acid

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di·hy·dro·pte·ro·ic ac·id

(dī-hī'drō-te-rō'ik as'id),
An intermediate in the formation of folic acid; a compound of 6-hydroxymethylpterin and p-aminobenzoic acid, the combining of which is inhibited by sulfonamides.

di·hy·dro·pte·ro·ic ac·id

(dī-hī'drop-ter-ō'ik as'id)
An intermediate in the formation of folic acid; a compound of 6-hydroxymethylpterin and p-aminobenzoic acid, the combining of which is inhibited by sulfonamides.
References in periodicals archive ?
Sulfonamides inhibit dihydropteroate synthase just like 4-aminobenzoic acid due to structural similarities.
Interhuman transmission as a potential key parameter for geographical variation in the prevalence of Pneumocystis jirovecii dihydropteroate synthase mutations.
Pyrimethamine and sulfadoxine can inhibit dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) enzymes.
Resistance to sulphadoxine and sulfa drugs arise from the accumulation of mutations at five codons in the dihydropteroate synthase (dhps) gene leading to amino acid change S436A, A437G, K540E, A581G, and S436F [18].
However, the mutations in folP [encoding the sulfonamide target the enzyme dihydropteroate synthase (DHPS)] are linked to sulphonamide resistance and the mtrR mutations or erm genes to macrolides resistance [15].
DNA extraction and PCR amplification of Pneumocystis jirovecii dihydropteroate synthase gene
[Gene polymorphisms in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes and structural modelling of the dhps gene in Colombian isolates of Toxoplasma gondii [in Spanish].
sulfanilamides are considered inhibitors of dihydropteroate synthetase.
Sull is dihydropteroate synthase which has almost exclusively been found on large conjugative plasmids and on class 1 integrons [27].
Potent drugs are required to treat certain organisms which are resistant to approved anti-biotic, therefore, there is always an overwhelming need for synthesis of new and effective anti-bacterial agents for the treatment of infections caused by antibiotic resistant pathogenic bacteria by targeting on enzyme; dihydropteroate synthase, which catalyze folic acid synthesis in bacteria and eukaryotes but not in humans.
Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihyrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy.
Dihydropteroate synthase of Mycobacterium leprae and dapsone resistance.
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