dihydrolipoamide dehydrogenase

(redirected from Dihydrolipoyl dehydrogenase)

di·hy·dro·lip·o·am·ide de·hy·dro·gen·ase

(dī-hī'drō-lip-ō-am'id dē-hī'drō-jen-ās'),
A flavoenzyme oxidizing dihydrolipoamide at the expense of NAD+; completes the oxidative decarboxylation of pyruvate; a part of several enzyme complexes (for example, α-ketoglutarate dehydrogenase complex). Decreased activity leads to neuronal loss in brain resulting in psychomotor retardation.

dihydrolipoamide dehydrogenase

(di?hi?dro-lip?o-am'id?)
The flavoprotein catalyst of the reoxidation of nicotinamide-adenine dinucleotide (NAD) or nicotinamide-adenine dinucleotide phosphate (NADP) by the mitochondrial electron transport chain. Synonym: diaphorase
References in periodicals archive ?
monodon acetyltransferase GE616028.1 - Dihydrolipoyl dehydrogenase P.
E-3 (dihydrolipoyl dehydrogenase) deficient form is a very rare form of MSUD.
In the bacterium Clostridium kluyveri an NAD(P)H-dependent flavoenzyme dihydrolipoyl dehydrogenase (synonymously called dihydrolipoamide dehydrogenase) reduces Fe(III) complexes of citrate, ATP, and ADP [2].
It consists of six different components: pyruvate decarboxylase (E1; EC 1.2.4.1), dihydrolipoic transacetylase (E2; EC 2.3.1.12), dihydrolipoyl dehydrogenase (E3; EC 1.8.1.4), two regulatory enzymes [PDH kinase (EC 2.7.1.99) and PDH phosphatase (EC 3.1.3.43)], and the E3-binding protein (3).
[5] Nonstandard abbreviations: PDHc, pyruvate dehydrogenase complex; E1, pyruvate decarboxylase; E2, dihydrolipoic transacetylase; E3, dihydrolipoyl dehydrogenase; TPP, thiamine pyrophosphate; PMS, phenazine methosulfate; INT, p-iodonitrotetrazolium violet; BSA, bovine serum albumin; DCA, dichloroacetic acid; DTT, dithiothreitol; PBS, phosphate-buffered saline; SMP, submitochondrial particle from bovine heart; MEF, mitochondria-enriched fraction; DQA, 2-n-decylquinazolin-4-yl-amine; and LD, lactate dehydrogenase.
The abnormal excretion of these branched compounds implies the need for differentiation from dihydrolipoyl dehydrogenase deficiency.

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