dihydrolipoic acid


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di·hy·dro·li·po·ic ac·id

(dī-hī'drō-lip-ō'ik as'id),
Reduced lipoic acid, formed by cleavage of the -S-S- bond as a result of the acceptance of two hydrogens. Compare: lipoic acid.
References in periodicals archive ?
Previous studies have shown that ALA and its reduced form dihydrolipoic acid have an amphiphilic property that allows them to easily cross the blood brain barrier and cell membranes and helps to activate other antioxidants such as vitamin C, vitamin E, coenzyme Q10, and ubiquinone [1, 28].
(10, 11) ALA and its derivative dihydrolipoic acid (DHLA) quench a number of reactive oxygen species in both lipid and aqueous phases, chelate transition metals, prevent membrane lipid peroxidation along with protein damage via interactions with vitamin C and glutathione and thus they are considered as potent antioxidants.
Subsequently, 6 x 10-2 M of sodium borohydride was added, and [alpha]-Lipoic acid was reduced to dihydrolipoic acid (DHLA), forming a clear solution after 30 min.
Alpha-lipoic acid is a hydrophilic and lipophilic acid that can be synthesized by plants and animals where it is metabolized to dihydrolipoic acid when captured by the cells [144].
Huge interest has been garnered in recent times on the antioxidant properties of a-LA and its reduced form dihydrolipoic acid (DHLA).
Due to its antioxidant property in both forms, oxidized (LA) and reduced (dihydrolipoic acid, DHLA), LA is called a "universal antioxidant." The LA/DHLA couple is a scavenger of superoxide anion radical ([O.sub.2.sup.*-]), hypochlorous acid (HOCl), peroxynitrite ([ONOO.sup.-]), and nitric oxide (*NO).
Alpha-lipoic acid (LA) and its reduced form, dihydrolipoic acid (DHLA), have received widespread attention as antioxidants with both preventative and therapeutic uses in humans and laboratory animals.
In addition to cellular energy production, lipoic acid and its reduced form, dihydrolipoic acid, are potent antioxidants that both directly and indirectly scavenge reactive oxygen species, free radicals, and peroxides that cause widespread oxidative stress and cellular damage.
Contrarily, the mechanisms underlying LA effects do not seem to involve direct oxidant scavenging, considering the low rate constants of their direct reactions with this cyclic disulfide or its reduction product dihydrolipoic acid (24).
Cakatay, "Redox homeostasis of albumin in relation to alpha-lipoic acid and dihydrolipoic acid," Oxidative Medicine and Cellular Longevity, vol.
(12) As an added benefit, it has also been demonstrated to significantly decrease the levels of Hemoglobin A1C (p<0.05), (13) Additionally, both lipoic acid and dihydrolipoic acid (DHLA), the reduced form of lipoic acid, have metal chelating capabilities.
Hence, the peak obtained with copper(n) present is considered to be as a result of the reducing reaction of the copper(I) complex formed with dihydrolipoic acid [8].

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