dihydroergotamine mesylate

Migranal

A nasal spray formulation of an ergot compound used to manage migraines, but not hemiplegic or basilar migraines and not as prophylaxis.
 
Adverse effects
Rarely: cardiac events, including coronary artery vasospasm, transient myocardial ischaemia or infarction, ventricular tachycardia and ventricular fibrillation. More commonly: burning sensation, dysgeusia, diarrhoea, dizziness, drowsiness, dry mouth, hot flushes, irritation, nasal congestion or dryness, nasal discharge, nausea, sinusitis, sore throat, exhaustion, weakness.

dihydroergotamine mesylate

(dī-hī″drō-ĕr-gŏt′ă-mēn)
A vasoconstrictor used in treating migraine.
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References in periodicals archive ?
STS101 is a drug-device combination of a proprietary dry-powder formulation of dihydroergotamine mesylate (DHE), which can be quickly and easily self-administered with a proprietary pre-filled, single-use, nasal delivery device.
It contains a reformulation of the drug dihydroergotamine mesylate (DHE) in a proprietary Tempo inhaler that allows DHE to be rapidly absorbed from the pleural mucosa into the systemic circulation.
Zogenix, Incorporated's sales force has initiated promotion of Migranal(dihydroergotamine mesylate, USP) Nasal Spray in the United States under the company's exclusive co-promotion agreement with Valeant Pharmaceuticals North America LLC.
Inpatients can be switched to intravenous DHE (dihydroergotamine mesylate) and outpatients can be given Migranal NS.
If headaches recur, treat attacks earlier, increase the dose, switch triptans, particularly to naratriptan or frovatriptan, add an NSAID, or switch to dihydroergotamine mesylate, Dr.
Dihydroergotamine mesylate Paddock Laboratories D.H.E.
by altering serotonin transmission through the use of serotonin receptor agonists (e.g., sumatriptan), lithium (e.g., lithium carbonate), tricyclic antidepressants (e.g., imipramine) or ergotamine alkaloids (e.g., dihydroergotamine mesylate, methysergide).
The triptans and possibly dihydroergotamine mesylate (DHE-45) can be very helpful for certain types of tension-type headaches, especially in patients who also get migraines.