STS101 is a drug-device combination of a proprietary dry-powder formulation of dihydroergotamine mesylate
(DHE), which can be quickly and easily self-administered with a proprietary pre-filled, single-use, nasal delivery device.
It contains a reformulation of the drug dihydroergotamine mesylate
(DHE) in a proprietary Tempo inhaler that allows DHE to be rapidly absorbed from the pleural mucosa into the systemic circulation.
Zogenix, Incorporated's sales force has initiated promotion of Migranal(dihydroergotamine mesylate
, USP) Nasal Spray in the United States under the company's exclusive co-promotion agreement with Valeant Pharmaceuticals North America LLC.
Inpatients can be switched to intravenous DHE (dihydroergotamine mesylate
) and outpatients can be given Migranal NS.
If headaches recur, treat attacks earlier, increase the dose, switch triptans, particularly to naratriptan or frovatriptan, add an NSAID, or switch to dihydroergotamine mesylate
Paddock Laboratories D.H.E.
by altering serotonin transmission through the use of serotonin receptor agonists (e.g., sumatriptan), lithium (e.g., lithium carbonate), tricyclic antidepressants (e.g., imipramine) or ergotamine alkaloids (e.g., dihydroergotamine mesylate
The triptans and possibly dihydroergotamine mesylate
(DHE-45) can be very helpful for certain types of tension-type headaches, especially in patients who also get migraines.