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hydrogenated ergotamine, an alpha-adrenergic blocking agent and vasoconstrictor used as ergotamine mesylate in treatment of migraine; administered intramuscularly, subcutaneously, intravenously, or intranasally.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


(dye-hye-droe-er-got-a-meen) ,

D.H.E. 45

(trade name),


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Therapeutic: vascular headache suppressants
Pharmacologic: ergot alkaloids
Pregnancy Category: X


Vascular headaches including:
  • Migraine,
  • Cluster headaches.


Vasoconstriction of dilated blood vessels by stimulating alpha-adrenergic and serotonergic (5-HT) receptors.
Larger doses may produce alpha-adrenergic blockade and vasodilation.

Therapeutic effects

Constriction of dilated carotid artery bed with resolution of vascular headache.


Absorption: Rapidly absorbed following IM and subcut administration and 32% absorbed from nasal mucosa.
Distribution: Unknown.
Protein Binding: 90%.
Metabolism and Excretion: Highly metabolized (90%) by the liver. Some metabolites are active.
Half-life: 10 hours.

Time/action profile (relief of headache)

Nasal within 30 minunknown unknown
IM, subcut15–30 min15 min–2 hr8 hr
IV <5 min15 min–2 hr8 hr


Contraindicated in: Peripheral vascular disease; Ischemic heart disease; Uncontrolled hypertension; Severe renal or liver disease ; Malnutrition; Known alcohol intolerance (injection only); Obstetric: Pregnancy; Lactation: Lactation; Concurrent use of CYP 3A4 enzyme inhibitors (macrolide anti-infectives and protease inhibitors).
Use Cautiously in: Illnesses associated with peripheral vascular pathology such as diabetes mellitus; Concurrent administration of other vasoconstricting agents; Pediatric: Children <6 yr (safety not established).

Adverse Reactions/Side Effects

Central nervous system

  • dizziness

Ear, Eye, Nose, Throat

  • rhinitis (most frequent)


  • myocardial infarction (life-threatening)
  • hypertension (most frequent)
  • angina pectoris
  • arterial spasm
  • intermittent claudication


  • abdominal pain (most frequent)
  • nausea (most frequent)
  • vomiting (most frequent)
  • altered taste
  • diarrhea
  • polydipsia


  • extremity stiffness
  • muscle pain
  • stiff neck
  • stiff shoulders


  • leg weakness
  • numbness or tingling in fingers or toes


  • fatigue


Drug-Drug interaction

Concurrent use of CYP 3A4 enzyme inhibitors (macrolide anti-infectives and protease inhibitors ) may produce serious, life-threatening peripheral ischemia and is contraindicated.Concurrent use with beta blockers, oral contraceptives, or nicotine (heavy smoking) may ↑ risk of peripheral vasoconstriction.Dihydroergotamine antagonizes the antianginal effects of nitrates.Concurrent use with vasoconstrictors may have ↑ effects (avoid concurrent use).Concurrent use with sumatriptan may result in prolonged vasoconstriction (allow 24 hr between use).


Intramuscular Subcutaneous (Adults) 1 mg; may repeat in 1 hr to a total of 3 mg (not to exceed 3 mg/day or 6 mg/wk).
Intramuscular Subcutaneous (Children ≥6 yr) 0.5 mg; may be repeated in 1 hr.
Intravenous (Adults) 0.5 mg; may repeat in 1 hr (not to exceed 2 mg/day or 6 mg/wk). For chronic intractable headache, 0.5–1 mg q 8 hr may be given until relief (not to exceed 6 mg/wk).
Intravenous (Children ≥6 yr) 0.25 mg; may be repeated in 1 hr.
Intravenous (Children and Adolescents 12–16 yr ) Severe, acute migraine—0.25–0.5 mg; 1–2 more doses may be given q 20 min.
Intravenous (Children 9–12 yr) Severe, acute migraine—0.2 mg; 1–2 more doses may be given q 20 min.
Intravenous (Children 6–9 yr) Severe, acute migraine—0.1–0.15 mg; 1–2 more doses may be given q 20 min.
Intranasal (Adults) 1 spray (0.5 mg) in each nostril, repeat after 15 min (2 mg total dose); not to exceed 3 mg/24 hr or 4 mg/wk.


Injection: 1 mg/mL (contains alcohol)
Nasal spray: 4 mg/1 mL in 1-mL ampules with nasal spray applicator

Nursing implications

Nursing assessment

  • Assess frequency, location, duration, and characteristics (pain, nausea, vomiting, visual disturbances) of chronic headaches. During acute attack, assess type, location, and intensity of pain before and 60 min after administration.
  • Monitor BP and peripheral pulses periodically during therapy. Report any increases in BP.
  • Assess for signs of ergotism (cold, numb fingers and toes; nausea; vomiting; headache; muscle pain; weakness).
  • Assess for nausea and vomiting. Ergotamine stimulates the chemoreceptor trigger zone. For adults, metoclopramide 10 mg IV may be administered 3–5 min before administration of dihydroergotamine IV. In children, metoclopramide or a phenothiazine antiemetic may be given orally as prophylaxis 1 hr before administration of dihydroergotamine IV. Oral administration may decrease risk of extrapyramidal and other side effects encountered with IV administration.
  • Toxicity is manifested by severe ergotism (chest pain, abdominal pain, persistent paresthesia in the extremities) and gangrene. Vasodilators, dextran, or heparin may be ordered to improve circulation.

Potential Nursing Diagnoses

Acute pain (Indications)
Risk for injury (Side Effects)


  • Administer as soon as patient reports prodromal symptoms or headache.
  • Intravenous Administration
  • pH: 3.4–4.9.
  • Dihydroergotamine may be administered undiluted.
  • Rate: Administer each dose over 1 min.
  • Syringe Compatibility:
    • promethazine.

Patient/Family Teaching

  • Instruct patient to use dihydroergotamine at the first sign of an impending headache and not to exceed the maximum dose prescribed.
    • Encourage patient to rest in a quiet, dark room after taking ergotamine.
    • Review symptoms of toxicity. Instruct patient to report these promptly.
    • Caution patient not to smoke and to avoid exposure to cold; these vasoconstrictors may further impair peripheral circulation.
    • May cause dizziness. Caution patient to avoid driving and other activities requiring alertness until response to the drug is known.
    • Advise patient to avoid alcohol, which may precipitate vascular headaches.
    • Instruct female patients to inform health care professional if they plan or suspect pregnancy. Dihydroergotamine should not be taken during pregnancy.
  • Intramuscular: Subcutaneous: Inject at the first sign of a headache and repeat at 1-hr intervals up to 3 doses. Once minimal effective dose is determined, adjust dose for subsequent attacks.
  • Intranasal: Instruct patient in proper use of nasal spray. Prime nasal sprayer 4 times before dose. Administer 1 spray to each nostril followed in 15 min by an additional spray in each nostril for a total of 4 sprays. Do not tilt head or sniff following spray. Do not use more than amount instructed. Discard ampule within 8 hr of opening. Do not refrigerate. Assembly may be used for 4 treatments; then discard.
    • Advise patient not to use Migranal to prevent a headache if there are no symptoms or if headache is different from typical migraine.
    • Instruct patient to notify health care professional if numbness or tingling in fingers or toes; pain, tightness, or discomfort in chest; muscle pain or cramps in arms or legs; weakness in legs; temporary speeding or slowing of heart rate; or swelling or itching occurs.

Evaluation/Desired Outcomes

  • Relief of pain from vascular headaches.
Drug Guide, © 2015 Farlex and Partners
References in periodicals archive ?
STS101 is a drug-device combination of a proprietary dry-powder formulation of dihydroergotamine mesylate (DHE), which can be quickly and easily self-administered with a proprietary pre-filled, single-use, nasal delivery device.
> Sumatriptan (Imitrex), zolmitriptan (Zomig), Octreotide (Sandostatin), dihydroergotamine. Verapamil (Calan, Verelan), topiramate (Topamax), and lithium carbonate for cluster headaches
The effect of ergotamine and dihydroergotamine or cerebral blood flow in man.
The amount of alkaloids produced was measured and compared with dihydroergotamine methane sulfonate standard salt.
The amount of alkaloids present was compared with dihydroergotamine methane sulphonate salt and bromocriptine mesylate salt.
Case reports also support the off-label use of sumatriptan and intravenous dihydroergotamine during attacks, she added.
Comparison of intravenous valproate versus intramuscular dihydroergotamine and metoclopramide for acute treatment of migraine headache.
Migraine-specific therapies include ergotamine and dihydroergotamine, and the "triptans."
Zogenix, Incorporated's sales force has initiated promotion of Migranal(dihydroergotamine mesylate, USP) Nasal Spray in the United States under the company's exclusive co-promotion agreement with Valeant Pharmaceuticals North America LLC.
* Dihydroergotamine (Migranol), an ergotamine derivative that is more effective and has fewer side effects than ergotamine.
Rescue therapy for acute migraine, part 1: triptans, dihydroergotamine, and magnesium.
Migranal is a dihydroergotamine available in formulations for subcutaneous injection and as a nasal spray.