There are arguments in the literature about whether chronic microaspiration can lead to diffuse interstitial fibrosis
, but at this point, that theory is purely conjecture, and a biopsy showing peribronchiolar fibrosis with bridging or a UIP-like pattern with peribronchiolar fibrosis is probably not caused by microaspiration.
Fulminating Diffuse Interstitial Fibrosis
of the Lungs.
Diffuse fibrosing alveolitis (diffuse interstitial fibrosis
of the lung): correlation of histology at biopsy with prognosis.
Inhalational talc has been associated with histological patterns of diffuse interstitial fibrosis
, nodular fibrosis, and foreign body granulomatosis .
Chest radiography showed diffuse interstitial fibrosis
with extensive emphysema in the upper lobes.
However in non-ischemic dilated cardiomyopathy, usually diffuse interstitial fibrosis
is observed and since it is hard to find a nonfibrotic reference point in myocardium at a diffuse fibrosis back-ground the implementation of delayed enhancement CMR is limited (7).
Honma and Chiyotani (1993) described diffuse interstitial fibrosis
(DIF) among workers with a variety of occupations (rock driller, stone mason, metal miner, tunneler, construction worker).
(5) Most of the other dusts that produce this type of bronchiolar pathology do not produce diffuse interstitial fibrosis
. Hence, this rationale is by no means limited to asbestos-induced fibrosis and suggests that bronchiolar disease and interstitial fibrosis are completely separate processes.
2 patients (66%) had bilateral diffuse interstitial fibrosis
. 1(33%) patient had bilateral lower lobe traction bronchiectasis.
Chronic diffuse interstitial fibrosis
of the lung in uranium miners.
"Diffuse interstitial fibrosis
with occasional subpleural intralobular cystic spaces.
(3,4) The 1997 Helsinki criteria incorporated these findings into more evidence-based criteria for the diagnosis of asbestosis, requiring (1) diffuse interstitial fibrosis
and (2) 2 or more asbestos bodies within a section area of 1 [cm.sup.2] or a count of uncoated asbestos fibers that falls into the range recorded by the same laboratory for asbestosis.