The curse of lymphatic filariasis: would the continual use of diethylcarbamazine
eliminate this scourge in Papua New Guinea?
is safe and effective causing rapid disappearance of microfilaria from circulation.
(iii) CAR + DEC group: mice subjected to carrageenan-induced pleurisy and diethylcarbamazine
(50 mg/Kg, oral route) three days prior to the carrageenan challenge (N = 10);
The anthelmintic drug, diethylcarbamazine
citrate (DECC), is a piperazine derivative (1).
By late 2011, at least one round of MDA using albendazole and diethylcarbamazine
had been conducted throughout all endemic areas of Haiti except the capital, Port-au-Prince.
Existing antifilarial drugs diethylcarbamazine
(DEC), ivermectin and albendazole are being used for the control for human filariasis, of which diethylcarbamazine
and ivermectin, are principally microfilaricidal with limited or no action on adult parasites (Sashidhara et al., 2012) and are not devoid of adverse reactions (Sharma 1990; Fan, 1992).
Elango, "A sensitive RP-HPLC method for simultaneous estimation of diethylcarbamazine
and levocetirizine in tablet formulation," Indian Journal of Pharmaceutical Sciences, vol.
The company is also committed to supply 2.2 billion tablets of DEC (Diethylcarbamazine
) free of charge to the World Health Organization (WHO).
In support of the London Declaration and the WHO's program to eliminate lymphatic filariasis, Eisai has signed an agreement with the WHO to extend its support until 2020, during which Eisai will supply free of charge 2.2 billion tablets of the medicine DEC (diethylcarbamazine
) until 2020, in line with the WHO elimination goals.
14) extraction Metronidazole (anti-inflammatory more than antihelmintic) Wound care Cutaneous Praziquantel 40 schistosomiasis mg/kg/day stat Sometimes repeated Systemic steroids in Katayama fever Avoidance of water in endemic areas Snail control Trypanosomiasis Nifurtimox (with gamma interferon Suramin, pentamidine Eflornithine WHO control measures Filarial Ivermectin elephantiasis Adjunctive albendazole, doxycycline Surgical correction DEC = diethylcarbamazine
; ANS = autonomic nervous system; GIT = gastrointestinal; CVS = cardiovascular system; CSF = cerebrospinal fluid; PCR = polymerase chain reaction.
Efficacy of diethylcarbamazine
and pirimiphos-methyl residual spraying in controlling brugian filariasis.