Others included vasodilators (dibenamine or dibenzyline
) to improve flow rates (Tindal, 1957).
Key products are Nilandron, for the treatment of metastatic prostate cancer; Dibenzyline
, for the treatment of pheochromocytoma; Lanoxin, for the treatment of mild-to-moderate heart failure and atrial fibrillation; and, Plaquenil, for the treatment of lupus and rheumatoid arthritis.
The labeling for the proprietary oral dosage form of phenoxybenzamine, Dibenzyline
, carries a warning regarding possible carcinogenic and mutagenic risks, as observed in in vitro and small animal testing (WellSpring Pharmaceutical Corporation, Sarasota, FL).
(6) These include local treatment with aluminum chloride hexahydrate (Drysol), antiperspirants, scopolamine, or phenoxybenzamine hydrochloride (Dibenzyline
Alpha blockers (including Dibenzyline
and Hytrin) and antispasmodic medicines (including Ditropan and Pro-Banthene) are sometimes prescribed to improve bladder emptying.
Agents such as sodium nitroprusside (Nipride), phentolamine mesylate (Regitine), and phenoxybenzamine hydrochloride (Dibenzyline
) have been recommended to counteract sympathetic reflex activity. Nitroprusside, however, should be used with caution in this population, because its effect of reducing blood pressure may also result in decreased cerebral perfusion pressure.
Examples of these antisympathetic drugs are prazosin (Minipress), phenoxybenzamine (Dibenzyline
), and terazosin (Hytrin).