Also found in: Dictionary, Encyclopedia.
Related to Diabinese: chlorpropamide, Orinase
trademark for a preparation of chlorpropamide, an oral hypoglycemic agent.
A trademark for the drug chlorpropamide.
a trademark for an oral antidiabetic (chlorproPAMIDE).
AcetohexamideA first-generation oral sulfonylurea used to reduce glucose in type 2 diabetics whose diabetes can’t be controlled by diet.
Mechanism of action Triggers release of insulin from the pancreas.
Pharmacokinetics Metabolised in liver to an active analogue; excreted via kidneys.
Adverse effects Hypoglycaemic reactions—e.g., coma, nausea, vomiting, dizziness, cholestatic jaundice, agranulocytosis, aplastic and haemolytic anaemia, hypersensitivity, skin reactions including photosensitivity, rash and itching.
Precautions Hypertension, liver and kidney disease, allergies