erythroleukemia

(redirected from Di Guglielmo's disease)
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erythroleukemia

 [ĕ-rith″ro-loo-ke´me-ah]
a malignant blood dyscrasia, one of the myeloproliferative disorders, with atypical erythroblasts and myeloblasts in the peripheral blood.
acute erythroleukemia a form of acute myelogenous leukemia representing erythroleukemia in which malignant leukocyte precursors have proliferated and become predominant.

e·ryth·ro·leu·ke·mi·a

(ĕ-rith'rō-lū-kē'mē-ă),
Simultaneous neoplastic proliferation of erythroblastic and leukoblastic tissues.

erythroleukemia

Di Guglielmo syndrome Hematology An acute myelocytic leukemia–FAB classification, M6, which is usually acquired affecting the elderly, but rarely also AD Clinical Anemia, fever, hepatosplenomegaly, hemorrhagic diathesis Lab ↑ Erythroblasts in circulation, BM, ↑ gammaglobulins, false positive positive rheumatoid factor, ANA, Coombs antiglobulin Genetics Aneuploidy–63%; cytogenetic defects, especially chromosomes 5 and 7 Prognosis Poor. See French-American-British classification.

e·ryth·ro·leu·ke·mi·a

(ĕ-rith'rō-lū-kē'mē-ă)
Simultaneous neoplastic proliferation of erythroblastic and leukoblastic tissues.
Synonym(s): erythroleukaemia.