dextrorphan


Also found in: Acronyms, Wikipedia.

dextrorphan

(dĕks-trōr'fan),
A metabolite of dextromethorphan.
Mentioned in ?
References in periodicals archive ?
MA weakly inhibited CYP1A2-mediated paracetamol formation and CYP2D1-mediated dextrorphan formation only at the highest concentration 100 [micro]M (Fig.
The mean dextromethorphan and dextrorphan urinary concentrations in addition to the standard deviations (SD) were computed for extensive and poor metabolizer groups independently.
Individual pharmacokinetic parameters of poor and extensive metabolizers, consisting of the urinary dextromethorphan and dextrorphan concentrations as well as the urinary metabolic ratios along with their means and standard deviations are displayed in Table 1.
Comparative pharmacology of levorphan, racemorphan and dextrorphan and related methyl ethers.
Dextromethorphan, dextrorphan, quinidine, chlorpheniramine, [beta]-nicotinamide adenine dinucleotide phosphate (NADP), D-glucose 6-phosphate, glucose 6-phosphate dehydrogenase, heparin sodium, urethane, and phenacetin were from Sigma Chemical Co.
Analysis of dextromethorphan and dextrorphan was a modified method.
[6] Nonstandard abbreviations: PM, poor metabolizer; UM, ultrarapid metabolizer; AS-PCR, allele-specific PCR; DXT, dextromethorphan; MR, metabolic ratio; SSPE, sodium chloride-sodium phosphate-EDTA; IM, intermediate metabolizer; EM, efficient metabolizer; and DRP, dextrorphan. Table 1.
Phenacetin, paracetamol, metacetamol, furafylline, testosterone, 6[beta]-hydroxytestosterone, corticosterone, ketoconazole, chlorpropamicle, chlorpheniramine, dextrorphan, dextromethorphan, chlorzoxazone, 6-hydroxychlorzoxazone, sodium diethyl-dithiocarbamate, n-glucose 6-phosphate (G6P), glucose 6-phosphate dehydrogenase (G6PDH), [beta]-nicotinamide adenine dinucleotide phosphate (NADP), and Tris-HC1 were pur-chased from Sigma Chemical Co.
Dextrorphan, dextromethorphan and chlorpheniramine (internal standard) were separated on Agilent ZORBAX Eclipse XDB-C8, 5[micro]M (150 mm x 4.6 mm) with Eclipse XDB-C8 guard column.
CYP2D6 activity was assessed by the formation of dextrorphan from the model CYP2D6 probe dextromethorphan.
2 showed that NF3 weakly inhibited CYP1A2-mediated paracetamol formation ([IC.sub.20] = 0.53 mg/ml), CYP2D6-mediated dextrorphan formation ([IC.sub.20] = 0.56 mg/ml), and CYP2E1-mediated 6-hydroxychlorzoxazone formation ([IC.sub.20] = 0.77 mg/ml).
RA inhibited CYP2C9-mediated 4-hydroxytolbutamide formation ([IC.sub.20] = 0.45 mg/ml), CYP2D6-mediated dextrorphan formation ([IC.sub.20] = 0.66 mg/ml), and CYP3A4-mediated 6[beta]-hydroxy-testosterone formation ([IC.sub.20] = 0.60 mg/ml) in pooled human liver microsomes.