dextrorphan


Also found in: Acronyms, Wikipedia.

dextrorphan

(dĕks-trōr'fan),
A metabolite of dextromethorphan.
Mentioned in ?
References in periodicals archive ?
6 [micro]M) and CYP2D6-mediated dextrorphan formation ([IC.
MA weakly inhibited CYP1A2-mediated paracetamol formation and CYP2D1-mediated dextrorphan formation only at the highest concentration 100 [micro]M (Fig.
The oxidative phenotype assignment for the population sample was based on the value of the subject's molar urinary ratio of dextromethorphan to dextrorphan (metabolic ratio) in relation to the anti-mode.
The mean dextromethorphan and dextrorphan urinary concentrations in addition to the standard deviations (SD) were computed for extensive and poor metabolizer groups independently.
6] Nonstandard abbreviations: PM, poor metabolizer; UM, ultrarapid metabolizer; AS-PCR, allele-specific PCR; DXT, dextromethorphan; MR, metabolic ratio; SSPE, sodium chloride-sodium phosphate-EDTA; IM, intermediate metabolizer; EM, efficient metabolizer; and DRP, dextrorphan.
Dextromethorphan, dextrorphan, quinidine, chlorpheniramine, [beta]-nicotinamide adenine dinucleotide phosphate (NADP), D-glucose 6-phosphate, glucose 6-phosphate dehydrogenase, heparin sodium, urethane, and phenacetin were from Sigma Chemical Co.
Analysis of dextromethorphan and dextrorphan was a modified method.
Phenacetin, paracetamol, metacetamol, furafylline, testosterone, 6[beta]-hydroxytestosterone, corticosterone, ketoconazole, chlorpropamicle, chlorpheniramine, dextrorphan, dextromethorphan, chlorzoxazone, 6-hydroxychlorzoxazone, sodium diethyl-dithiocarbamate, n-glucose 6-phosphate (G6P), glucose 6-phosphate dehydrogenase (G6PDH), [beta]-nicotinamide adenine dinucleotide phosphate (NADP), and Tris-HC1 were pur-chased from Sigma Chemical Co.
Dextrorphan, dextromethorphan and chlorpheniramine (internal standard) were separated on Agilent ZORBAX Eclipse XDB-C8, 5[micro]M (150 mm x 4.