dextran

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Related to Dextrans: dextran 40

dextran

 [dek´stran]
a water-soluble polysaccharide of glucose produced by the action of Leuconostoc mesenteroides on sucrose; used as an artificial plasma extender.

dex·tran

(deks'tran),
1. Any of several water-soluble high molecular weight glucose polymers (ranging between MW 1,000 and 40,000,000); produced by the action of members of the family Lactobacillaceae and certain other microorganisms on sucrose; used in isotonic sodium chloride solution for the treatment of shock, and in distilled water for the relief of the edema of nephrosis; lower molecular weight dextran (for example, MW 40,000 designated as dextran 40) improves blood flow in areas of stasis by reducing cellular aggregation.
See also: dextransucrase.
2. α-1,6-glucan with branch points (1,2; 1,3; 1,4) that are spaced in a manner characteristic of the individual species; used as plasma substitutes or expanders.
See also: dextransucrase.

dextran

(dĕk′străn′, -strən)
n.
Any of a group of branched polysaccharides with various molecular weights that are used to prevent thrombosis, as plasma volume expanders, and as food additives.

dextran

Transfusion medicine Dextran-40, dextran-70, dextran-1 A colloid-type volume expander consisting of a large glycogen-like molecules which may occasionally be used in surgical blood management by hemodilution; these substances have the desired properties of being viscid, and gelatinous, resulting in oncotic pressure to retain fluids in vessels; they are widely used as replacement fluids and volume expanders Pros ↓ Allogeneic transfusions, ↓ postoperative bleeding, ↓ blood viscosity Cons Interferes with platelet and RBC function, crossmatching; may cause anaphylaxis and peripheral edema. See Colloid solutions, Crystalloids, Hemodilution, Surgical blood management.

dex·tran

(deks'tran)
Any of several water-soluble high molecular weight glucose polymers; used in isotonic sodium chloride solution for the treatment of shock, and in distilled water for the relief of the edema of nephrosis; lower molecular weight dextran.
See also: dextransucrase

dex·tran

(deks'tran)
Any of several water-soluble high molecular weight glucose polymers; used in isotonic sodium chloride solution to treat shock and to relieve edema of nephrosis.
References in periodicals archive ?
SEM revealed the surface morphologies of the freeze dried dextrans. At the low magnification of 200x and 500x (Figures 2(a) and 2(b)), it appeared as fibrous groups that folded with each other while, at the higher magnification of 1000x and 5000x (Figures 2(c) and 2(d)), a network of sheets permeated with pores was observed.
Dextran is also an excellent biocompatible polysaccharide for hydrophilic coating.
The permeability of epithelial junctions was probed with small (<1 kDa) fluorescent dyes (Bodipy, Life Technologies; and CF 488, Biotium, Fremont, CA) and fluorescein-conjugated dextrans (4, 10, 40, and 70 kDa, Life Technologies; 147 kDa, Sigma-Aldrich, St.
The dextrans from the new strain may act as so-called prebiotics, non-digestible food ingredients that stimulate the growth or activity of bacteria in the digestive system and which are beneficial to health.
Interestingly, the 70 kDa dextran accumulated in the microsphere walls to levels exceeding its concentration in solution, a behavior not seen with any of the larger or smaller dextrans (Fig.
Tenkanen said: "The advantage of this new strain of bacteria is that while it produces 10 times more dextran than products on the market now, it doesn't produce large amounts of acid.
Other studies have demonstrated life-threatening acute reactions with iron dextran, including respiratory arrest, hypotension, syncope, and dyspnea, as well as delayed, nonlethal reactions that included myalgia, arthralgia, and pulmonary embolus (Hamstra, Block, & Schocket, 1980; Woodman, Shaw, Shipman, & Edwards, 1987).
Some biopolymers that have worked in this application include the celluloses, starches, alginates, caseinates, gelatines and dextrans, which often exhibit phase separation in foods.
Contrary to native dextrans, temperature has a strong effect on the viscometric parameters of amphiphilic dextrans.
Protection by the dextrans is suggested to result from their ability to balance the osmotic pressure across the permeabilized cell membrane, which will reduce the flow of water through the hemolytic pore and into the cell and will prevent swelling and lysis [8].