Unlike fenfluramine and dexfenfluramine
, phentermine was not withdrawn from the market at that time.
Furthermore, removal of some approved antiobesity drugs (fenfluramine, dexfenfluramine
, sibutramine, rimonabant) because of safety issues might be a possible explanation for the reluctance of some physicians to prescribe this class of drugs.
The drugs in question were Redux (dexfenfluramine
FDA announces withdrawal fenfluramine and dexfenfluramine
Amphetamines used in weight management, such as sibutramine, fenfluramine and dexfenfluramine
, have been involved with cardiovascular side effects such as hypertension and pulmonary arterial hypertension (3-5).
2009) (discussing the Vioxx Settlement Agreement and its authorizations to the court); In re Diet Drugs (Phentermine, Fenfluramine, Dexfenfluramine
Robertson, "Effects of the cannabinoid receptor antagonist SR 141716, alone and in combination with dexfenfluramine
or naloxone, on food intake in rats," Psychopharmacology, vol.
Anorectic drugs such as dexfenfluramine
(Dfen) have been shown to induce PAH only in female mice .
Although still available in many countries, phentermine and diethylpropion were largely superseded by the serotonin (5-HT)-releasing agents fenfluramine and dexfenfluramine
. It was known from the outset that agents of this series had the potential to produce primary pulmonary hypertension, but the risk was deemed sufficiently low against the weight loss benefits.
Effects of preexposure to dexfenfluramine
, phentermine, dexfenfluraminephentermine, or fluoxetine on sibutramine-induced hypophagia in the adult rat.
Cardiac valvulopathy associated with exposure to fenfluramine or dexfenfluramine