Developmental Toxicity

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the quality of being poisonous, especially the degree of virulence of a toxic microbe or of a poison.
developmental toxicity the extent to which a toxin produces adverse effects on a developing embryo or fetus; see also teratogenesis.
maternal toxicity a toxic effect on a pregnant woman or nursing mother, as opposed to one affecting an embryo, fetus, or nursing infant.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
The occurrence of adverse effects on a developing organism attributed to exposure to a chemical before conception, in utero, after birth, or during sexual maturation
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The in vitro developmental toxicity data of the DMSO-extracts of 9 PS and 2 GTL products, as tested in the EST, were taken from our previous study (Kamelia et al., 2017).
Reproductive and developmental toxicity. Different windows of susceptibility (WOS) related to reproductive and developmental and other noncancer effects are studied.
Developmental toxicity evaluation of triclopyr butoxyethyl ester and triclopyr triethylamine salt in the CD rat.
Nakamura, "Reproductive and developmental toxicity study on sodium hyaluronate (SH)--(1) Study on subcutaneous administration to rats during the period of organogenesis," Japanese Pharmacology and Therapeutics, vol.
Absence of Prenatal Developmental Toxicity from Inhaled Arsenic Trioxide in Rats.
In addition to elevated cancer risk and disruption of the endocrine system, growing evidence supports developmental toxicity from prenatal or early postnatal exposure to PAHs (Perera et al., 2003).
Moreover, the underlying mechanisms behind the developmental toxicity of compounds known to have a teratogenic potential has solely partially elucidated if any (1).
Developmental toxicity is shown by the disubstituted methyl-, butyl-, and octyltins, but not by the corresponding monosubstituted compounds.
The International Scientific Committee at the International Conference on Fetal Programming and Developmental Toxicity (Faroe Islands, May 2007) stated in a position paper: "The old paradigm, developed over four centuries ago by Paracelsus, was that 'the dose makes the poison.' However, for exposures sustained during early development, the most important issue is that 'the timing makes the poison.' This extended paradigm deserves wide attention to protect the fetus and child against preventable hazards."
Developmental toxicity has not been proven, but more studies are needed regarding the potential for behavioral toxicity after long-term in utero exposure.
"This study confirms that, as we have suspected, exposure to (perfluorooctane sulfonate and perfluorooctanoate) is fairly universal; this is of particular concern because of the potential toxicity, especially developmental toxicity, for these chemicals and the lack of information about health risks at these exposure levels," said APHA member Lynn Goldman, MD, MPH, co-author of the study.
NTP-CERHR Expert Panel Report on the Reproductive and Developmental Toxicity of Soy Formula.

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