USP8

USP8

A gene on chromosome 15q21.2 that encodes an enzyme which deubiquitinates target proteins (e.g., BIRC6, KIF23, STAM2, RASGRF1, ESCRT-0, EGFR, EPS15,  RASGRF1, RNF41, YWHAE, YWHAG and YWHAZ), preventing their degradation and thus playing an important regulatory role in protein turnover.