Hashimoto et al., "Usefulness of enzyme-linked immunosorbent assay using recombinant desmogleins
1 and 3 for serodiagnosis of pemphigus," British Journal of Dermatology, vol.
In pemphigus vulgaris, there is binding of autoreactive IgG to desmosomal proteins (desmogleins
) causing the loss of keratinocyte cohesion.
In the area of the macula adherens, desmogleins
and desmocollins provide the linkage between the plasma membranes of adjacent cells.
Desmosomes form the adhesive core of intercellular junctions, which consist of desmosomal Cadherins, desmogleins
(Dsgs), and desmocollins (figure 1).
are one of the major glycoproteins of the desmosomal structure found in epithelial cells.
Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering disease mediated by autoantibodies (autoAbs) directed against desmogleins
(Dsg) located on the surface of keratinocyte cells (KC).
1 and 3 in the companion layer anchor mouse anagen hair to the follicle," Journal of Investigative Dermatology, vol.
are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2, Dsg3, and Dsg4.