desmoglein

(redirected from Desmoglein 3)

desmoglein

(dĕz″mō-glē′ĭn)
A cell surface molecule typically found in desmosomes that makes skin cells adhere to each other. Autoantibody disruption of cellular adhesion by desmogleins results in pemphigus. Disruption of desmogleins by staphylococcal toxins is responsible for the blistering of the skin seen in staphylococcal scalded skin syndrome.
References in periodicals archive ?
The currently known target antigens are desmoglein 1 (Dsg1), desmoglein 3 (Dsg3), and plakin protein, which act as adhesion molecules between keratinocytes in the epidermis.
Autoantibodies are produced against desmoglein 3 or both desmoglein 1 and desmoglein 3 in pemphigus vulgaris.
132) However, over-expression of certain adhesion proteins, such as claudin 1 (133) and desmoglein 3, (134) can enhance invasion.
Desmoglein 3, its pathogenecity and a possibility for therapeutic target in pemphigus vulgaris.
The underlying mechanism involves the formation of autoantibodies against the cadherin-type adhesion molecules desmoglein 3 mainly.
Desmoglein 3 protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris and plays important roles in human squamous cell cancer.
Bu adezyon molekullerinden desmoglein 1 (Dsg1) ve desmoglein 3 (Dsg3) en iyi tanimlanmis olanlardir.
Blisters occur in the epidermis and the mucous membranes, where the IgG autoantibodies target two structural proteins of the desmosomes identified as desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3).
Immunologic testing of this patient showed that in addition to antibodies against desmoglein 1, she began making high-titer auto-antibodies against desmoglein 3 and had transformed into PV
Markers Commonly Used for Separating Squamous Cell Carcinoma (SCC) From Adenocarcinoma (ADC) Antibody SCC ADC TTF1 + Napsin A - + p40 + - CK5/6 + - CK5 + - p63 - (diffuse pattern) - Desmoglein 3 + - Abbreviations: CK, cytokeratin; TTF1, thyroid transcription factor 1; +, greater than 75% of cases are positive; -, less than 5% of cases are positive.