Monitoring disease activity in pemphigus with enzyme-linked immunosorbent assay using recombinant desmoglein
1 and 3.
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein
3, its pathogenecity and a possibility for therapeutic target in pemphigus vulgaris.
Mayberry, Sr., Professor of Pathology and Toxicology at Northwestern University Feinberg School of Medicine, said that Desmoglein
1 is best understood as the 'glue' that holds the outer layer of human skin together.
HAdV-B3 is a representative of the species B types that utilize CD46 and/or desmoglein
2 (DSG2) as attachment receptors [39,43,44].
The Sey mouse corneal epithelium contains decreased levels of desmoglein
, [beta]-catenin, [gamma]-catenin, and keratin-12, consistent with defective intercellular adhesion .
They are inclusive of integral proteins (desmoglein
and desmocollin), cytoplasmic adapter proteins (desmoplakin and plakoglobin) and plaque associated proteins (plakophilin, envoplakin, and periplakin).
Three such markers are Napsin A, Desmoglein
3 and p4-0.