desmoglein


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desmoglein

(dĕz″mō-glē′ĭn)
A cell surface molecule typically found in desmosomes that makes skin cells adhere to each other. Autoantibody disruption of cellular adhesion by desmogleins results in pemphigus. Disruption of desmogleins by staphylococcal toxins is responsible for the blistering of the skin seen in staphylococcal scalded skin syndrome.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Monitoring disease activity in pemphigus with enzyme-linked immunosorbent assay using recombinant desmoglein 1 and 3.
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1.
Desmoglein 3, its pathogenecity and a possibility for therapeutic target in pemphigus vulgaris.
Mayberry, Sr., Professor of Pathology and Toxicology at Northwestern University Feinberg School of Medicine, said that Desmoglein 1 is best understood as the 'glue' that holds the outer layer of human skin together.
HAdV-B3 is a representative of the species B types that utilize CD46 and/or desmoglein 2 (DSG2) as attachment receptors [39,43,44].
The Sey mouse corneal epithelium contains decreased levels of desmoglein, [beta]-catenin, [gamma]-catenin, and keratin-12, consistent with defective intercellular adhesion [83].
They are inclusive of integral proteins (desmoglein and desmocollin), cytoplasmic adapter proteins (desmoplakin and plakoglobin) and plaque associated proteins (plakophilin, envoplakin, and periplakin).