Terbinafine and itraconazole are each approved by the US Food and Drug Administration for 3 months of daily dosing to treat toenail onychomycosis due to dermatophytes
. (17,18) An intermittent approach is also used (Table 2), (19) with booster therapy as needed at 6, 9, and 12 months.
Despite the fact that the culture media without cycloheximide have somewhat lost their appeal due to the inability of certain dermatophytes
to sporulate, our experience suggests that they can be useful not exclusively for primary sterile samples.
(Table 1) Among all the dermatophytes
isolated, maximum incidence was seen of Trichophyton species, that too of Trichophyton mentagrophyte (38.46%), followed by Trichophyton tonsurans (23.07%) and Trichophyton rubrum (20.51%) (Figure 3).
The wealth and abundance of organisms were determined and found dermatophytes
27%, non-dermatophytes 49% and yeasts 24%, corresponding to: Candida albicans 17% (9), Candida glabrata 6% (3), Trichophyton mentagrophytes 8% (4), Trichophyton rubrum 4% (2), Trichophyton tonsurans 6% (3), Microsporum canis 6% (3), Scopulariopsis brevicaulis 12% (6), Fusarium solani 19% (10), Penicillium sp.
Conclusion: Our finding provide information about the possible role of free amino acids in pathogenicity of dermatophytes
It was concluded that uniplex PCR can be used for accurate diagnosis of dermatophytes
The antifungal activity was screened using dermatophytes
and the Candida albicans (MTCC code: 3017) species.
Dermtophytes appear to be the chief organisms responsible for the infection though onychomycosis can be caused by non dermatophyte
moulds and yeasts also4.
In Ethiopia, studies conducted on dermatophytosis are few and these studies are concentrated on tinea capitis caused by dermatophytes
primarily in children of school age [17-20].
Kruger et al., "Molecular biological detection of dermatophytes
in clinical samples when onychomycosis or tinea pedis is suspected: A prospective study comparing conventional dermatomycological diagnostics and polymerase chain reaction," Hautarzt, vol.
In addition, it has been shown that nails infected with dermatophytes
grow at a slower rate than uninfected nail plates, proportional to amount of nail affected .