dermatan sulfate

(redirected from Dermatan)

der·ma·tan sul·fate

an anticoagulant with properties similar to those of heparin and sharing with heparin a sulfated mucopolysaccharide structure; a repeating polymer of l-iduronic acid and N-acetyl-d-galactosamine. O-Sulfation of iduronic acid residues at the C-2 position and of galactosamine residues at the C-4 and C-6 positions occurs to a variable extent.

dermatan sulfate

(dûr′mə-tăn′)
n.
A glycosaminoglycan that is a structural component of certain body tissues, especially the skin.

der·ma·tan sul·fate

(dĕrmă-tan sŭlfāt)
Anticoagulant with properties similar to those of heparin.

dermatan sulfate

a component of the acellular ground substance of skin.
References in periodicals archive ?
Collagen confers strength, elastin provides elasticity, and the glycosaminoglycans such as hyaluronic acid, heparan sulfate, and dermatan sulfate bind water, impart volume to the skin, and provide support for important cell-to-cell communication.
MPS VII is a rare genetic, metabolic lysosomal storage disorder (LSD) caused by the deficiency of beta-glucuronidase, an enzyme required for the breakdown of the glycosaminoglycans (GAGs) dermatan sulfate, chondroitin sulfate and heparan sulfate.
64) There are 2 main types of GAGs: nonsulfated GAG (hyaluronic acid) and sulfated GAG (heparan sulfate and heparin, chondroitin sulfate, dermatan sulfate, keratin sulfate, versican, and decorin).
Endocan is a dermatan sulphate proteoglycan molecule.
Compounds like heparan, heparan sulfate, chondroitin sulfate, dermatan sulfate and keratan sulfate belong to this class.
GAG family include unsulphated hyaluronic acid (HA), sulphated dermatan sulphate (DS), keratin sulphate (KS), heparin sulphate (HS) and chondroitin sulphates (C4S, C6S).
2) In this condition there is accumulation of mucopolysaccharides, dermatan sulfate, heparin sulfate in the lysosomes leading to cellular dysfunction.
Heparan sulfate and dermatan sulfate derived disaccharides are sensitive markers for newborn screening for mucopolysaccharidoses types I, II and III.
Within these fibres lie a variety of molecules, such as hyaluronic acid, dermatan sulphate and chondroitin sulphate, which absorb and retain water (up to 1000 times their own weight) and control the movement of solutes through the skin.
Thus, dermatan sulfate was removed from isolated GAGs samples using depolymerisation with chondroitinase B (from Flavobacterium heparinum); then, the mixture of heparinase I and heparinase III (both from Flavobacterium heparinum) was added to a reaction medium in order to remove heparin sulfate/heparin.
El cofactor II de la heparina es otra serpina, que inhibe a la trombina en presencia de heparan o dermatan sulfato.