dermatan sulfate

(redirected from Dermatan)

der·ma·tan sul·fate

an anticoagulant with properties similar to those of heparin and sharing with heparin a sulfated mucopolysaccharide structure; a repeating polymer of l-iduronic acid and N-acetyl-d-galactosamine. O-Sulfation of iduronic acid residues at the C-2 position and of galactosamine residues at the C-4 and C-6 positions occurs to a variable extent.
Farlex Partner Medical Dictionary © Farlex 2012

dermatan sulfate

(dûr′mə-tăn′)
n.
A glycosaminoglycan that is a structural component of certain body tissues, especially the skin.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

der·ma·tan sul·fate

(dĕrmă-tan sŭlfāt)
Anticoagulant with properties similar to those of heparin.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Specifically, odiparcil acts on chondroitin sulfate ("CS") and dermatan sulfate ("DS"), either or both of which accumulate in patients with MPS I, II, IVa, VI and VII.
It was shown that loss of sulfated proteoglycans and anionic regions in the basal membrane of the glomerulus and the mesangial mat rix caused excess accumulation of proteoglycans such as chondroitin sulphate and dermatan sulphate in these areas.3 This causes a decrease in charge-dependent renal selectivity and an increase in the thickness of the basal membrane.
Odiparcil has also the potential to address other MPS types, characterized by the accumulation of chondroitin or dermatan sulfate (MPS I or Hurler/Sheie syndrome, MPS II or Hunter syndrome, MPS IVa or Morquio syndrome and MPS VII or Sly syndrome).
Hastalik, iduronat-2-sulfataz enzim eksikligi nedeniyle yikilamayan dermatan ve heparan sulfat gibi glukoazminoglikanlarin (GAG) solunum, sinir, dolasim ve kas-iskelet sistemlerinde birikmesi ile karakterizedir.
Epidural fibrosis is a natural response of the body to the impact of surgery, leading to marked reduction in the cellularity of the tissue and excessive deposition of the extracellular matrix components such as collagen, fibronectin, and dermatan sulfate.
60 kDa) (Rodrigues et al., 2013), dermatan sulfate (DS) and/or heparan sulfate (HS) (Salles et al., 2017).
MPS II is a genetic lysosomal storage disease caused by deficiency of the iduronate-2-sulfatase enzyme which is needed to break down or recycle glycosaminoglycans dermatan sulfate and heparan sulfate.
Decorin (DCN) is one of the most common dermatan sulphate proteoglycan (molecular protein polysaccharide) with small leucine rich proteins.
Generally, dermatan sulphate deposition in the MPS syndromes results cardiac valve problems.
Urine dermatan sulphate concentrations were elevated in both of them and the gross elevations of plasma beta-hexosaminidase, arylsulphatase A and alphamannosidase were consistent with a diagnosis of ML II/III.