dermatan sulfate

(redirected from Dermatan)

der·ma·tan sul·fate

an anticoagulant with properties similar to those of heparin and sharing with heparin a sulfated mucopolysaccharide structure; a repeating polymer of l-iduronic acid and N-acetyl-d-galactosamine. O-Sulfation of iduronic acid residues at the C-2 position and of galactosamine residues at the C-4 and C-6 positions occurs to a variable extent.

dermatan sulfate

(dûr′mə-tăn′)
n.
A glycosaminoglycan that is a structural component of certain body tissues, especially the skin.

der·ma·tan sul·fate

(dĕrmă-tan sŭlfāt)
Anticoagulant with properties similar to those of heparin.

dermatan sulfate

a component of the acellular ground substance of skin.
References in periodicals archive ?
The major classes of GAG include hyaluronic acid (HA), heparin sulphate, heparin, chondroitin 4-sulphate, chondroitin 6-sulphate, dermatan sulphate and keratan sulphate.
Skeletal survey of the child revealed features suggestive of mucopolysaccharidosis 1H (Hurler syndrome), which was further confirmed by quantitative and qualitative urinary glycosoaminoglycan (GAG) analysis [1] revealing elevated levels of dermatan and heparan sulphate.
Examples are sulfur-containing amino acids (methionine and cysteine), which are necessary for the construction of protein structures and lead to basic substances of connective tissue (glycoproteins such as chondroitin, dermatan, and heparan).
Dermatan sulfate proteoglycans from the mineralized matrix of the avian eggshell.
Proteoglycans are glycoproteins that have a core protein with one or more covalently attached glycosaminoglycan (GAG) chains such as chondroitin sulfate and dermatan sulfate.
MPS 7 is caused by the deficiency of beta-glucuronidase, an enzyme required for the breakdown of the glycosaminoglycans (GAGs) dermatan sulfate and heparan sulfate.
Chondroitin sulfate, the dominant human glycosaminoglycan, together with hyaluronic acid comprise the majority found by amniotic fluid analysis; heparin sulfate and dermatan sulfate are present in small amounts and undetectable in healthy pregnancies, respectively.
We also went on to monitor long-term clinical outcomes in patients with MPSI, MPSII and MPSVI after treatment to show that elevations of both this biomarker, and the dermatan sulphate:chondroitin sulphate biomarker currently used in the diagnostic laboratory in Manchester, correlated with clinical treatment outcomes in patients.
Other examples of glycosaminoglycans in the human body include chondroitin sulfates, ketatan sulfate, heparin, heparan sulfate, and dermatan sulfate.
Candidate polysaccharide or proteoglycan subunits include aggrecan, agrin, bamacan, heparan sulfate, chondroitin sulfate, keratan sulfate, versican, phosphocan, perlecan, hyaluronan, decorin, dermatan sulfate, biglycan, fibromodulin, alginate, polylactate, polyglycolic acid, starch, dextran, agarose, chitan, chitosan, and heparin.
Eggshell membranes contain fibrous proteins such as collagen, but have also been shown to contain glycosaminoglycans (GAGs) such as dermatan sulfate and chondroitin sulfate, hexosamines such as glucosamine, and significant amounts of hyaluronic acid, all important ingredients in joint care.