derivative chromosome


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de·riv·a·tive chro·mo·some

an anomalous chromosome generated by translocation.
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Other reported genetic abnormalities include supernumerary ring chromosomes and a derivative chromosome 13 segment, (13) translocation t(2; 6)(q31; p21.3) as the only cytogenetic abnormality, (29) and 2 cases with genetic variability but both with chromosome 7 gains.
Of particular interest, a triplicate segment on the derivative chromosome 11 at bands q22-q25 containing the MLL gene was detected (arrow in Figure 3, A).
The 5' EWSR1 end of the probe remains on the derivative chromosome 22, whereas the 3' EWSR1 end of the probe moves to the derivative chromosome 12.
B, An interphase nucleus showing abnormal signal patterns for the derivative chromosomes 8 and 21 from an acute myelogenous leukemia case with t(8;21)(q22;q22).
In these patients, loss of fertility is mainly caused by the high prevalence of gametes that have lost or gained chromosome material as a result of the rearrangement of the derivative chromosomes or a generation of a recombinant chromosome.