deprenyl


Also found in: Dictionary, Wikipedia.
Related to deprenyl: L-deprenyl, Hydergine

de·pre·nyl

(dē'pren-il),
A noncompetitive inhibitor of monoamine oxidase selective for the type B isozyme, which is responsible for oxidative deamination of dopamine in the brain. The drug is used as an antiparkinsonian agent.
Synonym(s): deprenil

deprenyl

Alternative pharmacology
A prescription drug used to treat Parkinson’s disease, which has acquired currency among some practitioners of alternative medicine as an anti-ageing substance; deprenyl acts on the substantia nigra., a region of the brain that is believed to age more rapidly than others, by blocking the degradation of dopaminergic neurotransmitters.

deprenyl

Eldepryl, selegiline A selective irreversible inhibitor of type B monoamine oxidase that delays the onset of disability in Pts with early untreated Parkinson's disease–PD. See MPTP.
References in periodicals archive ?
The dichloromethane extract (0.001 to 100 [micro]g/mL), purified compounds ([10.sup.-9] to [10.sup.-2] M), and standard MAO inhibitors (phenelzine, clorgyline, and deprenyl) ([10.sup.-12] to [10.sup.-5] M) were tested on human MAOA and MAO-B enzymes [19].
The Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) study was designed to investigate the potential for selegiline to modify the disease course in early PD.
Increased effectiveness of tacrine by deprenyl co-treatment in rats: EEG and behavioural evidence.
Exogenous analogues of these compounds are antidepressants such as pargyline, deprenyl, and so on.
No menciona el Deprenyl, la bromocriptina, la L-dopa etc.
Although 100 mg/kg gentamicin (sc) led to nephrotoxicity at 24 hr, no hepatotoxicity was associated with it, nor was hepatotoxicity detected with deprenyl or lazabemide.
Serotonin syndrome and the combined use of deprenyl and an antidepressant in Parkinson Es disease.
Formerly Deprenyl Research Ltd., Draxis Health is engaged
(Mirapex) Anticholinergics, amantadine and deprenyl Trihexyphenidyl (Artane) May help reduce tremor and to a Apo-trihex lesser extent, bradykinesia and Benztropine (Cogentin) rigidity.
Deprenyl, a monoamine oxidase B inhibitor is known to upregulate activities of antioxidant enzymes such as superoxide dismutase and catalase in brain's dopaminergie regions.
Meanwhile, ambitious men in the US are increasingly turning to ``smart'' drugs like Deprenyl, which enhances so-called lifestyle characteristics like aggressiveness, territoriality, accomplishment, sexuality and achievement.
Determination of enantiomeric metabolites of L-deprenyl, o-methamphetamine, and racemic methamphetamine in urine by capillary electrophoresis: comparison of deprenyl use and methamphetamine use.