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Moreover, although the various members of the Kv1 family have different signaling and little is known about their exact roles in disease and physiology, it is well established that these channels are involved in cell membrane hyperpolarization, and their blockade is associated with increased membrane depolarization and cellular excitability with the potential of the development of seizures, atrial fibrillation, and arterial myogenic vasoconstriction (5,6), which might potentiate ischemic events that may accidently occur during the application of the therapy or even help their precipitation.
Besides, the inhibition of the mitochondrial respiratory chain described above by decavanadate can lead to sustained mitochondrial depolarization which is lethal for cells demanding a high supply of metabolic energy.
In the present study, Y25130 (a 5-H[T.sub.3] receptor antagonist) and RS39604 (a 5-H[T.sub.4] receptor antagonist) blocked SCRT-induced membrane depolarizations, whereas SB269970 (a 5-H[T.sub.7] receptor antagonist) did not.
Indeed, injury depolarizations worsen tissue and neurological outcome in focal cerebral ischemia and other brain injury states including aneurysmal SAH [20,29,31,57,63].
3A): the soma recording shows a sustained, slow depolarization (i.e., the DP) with attenuated sharp deflections that are synchronous with the overshooting impulses arising from a flat baseline recorded from the axon (Watanabe et al., 1967b, Squilla oratorio; Tazaki, 1970, Eriocheir japonicus; Tazaki, 1973, Panulirus japonicus; Tazaki and Cooke, 1983a, Portunus sanguinolentus).
As stimulation frequency increased, the response became biphasic, with progressively shorter periods of hyperpolarization followed by depolarization. In most preparations, maximum depolarization occurred at a stimulating frequency of 40 Hz.
Using vertical profile measurements with our ALS300 system and calibration of the volume depolarization in a molecular reference layer (height interval: 4000-4500 m), a cross-calibration constant [K.sup.*] = 20.9 [+ or -] 0.7 was obtained.
The QT interval is equal to the depolarization plus repolarization periods of the heart.
A related method, which is known as the thermally stimulated depolarization current, or TSDC technique, has come to be regarded as a viable method for studying the relaxation properties of polymers.
Methods: The present study aims to characterize changes in [Na.sup.+] currents on depolarization and transient inward currents (Iti) on repolarization.