The orphan RetS protein binds to GacS protein thereby, inhibiting its ability to autophosphorylate using ATP and also stimulating the dephosphorylation
of GacS~P (76).
Pfeifer, "The tumor suppressor RASSF1A prevents dephosphorylation
of the mammalian STE20-like kinases MST1 and MST2," The Journal of Biological Chemistry, vol.
Deng, "Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation
," The Journal of Biological Chemistry, vol.
First, the constant rate of PIP3 dephosphorylation
in AML cells is lower than normal cells as a result of various abnormal mechanisms in the PI3K signal upstream pathway, for example, PTEN deletion .
Mizuno, "Calcium signalinduced cofilin dephosphorylation
is mediated by Slingshot via calcineurin," The Journal of Biological Chemistry, vol.
Kim, "Melatonin synergistically enhances cisplatin-induced apoptosis via the dephosphorylation
of ERK/p90 ribosomal S6 kinase/heat shock protein 27 in SK-OV-3 cells," Journal of Pineal Research, vol.
Proline-independent ser/thr residues are phosphorylated by non-PDPKs such as calcium/calmodulin-activated PKII, microtubule affinity-regulated kinase 110, PKA, and casein kinase 1. Protein phosphatase 2A (PP2A) accounts for approximately 70% of all tau dephosphorylation
activity in the human brain.
However, ratio of dCK and cytosolic 5'-nucleotidase II (cN-II), which inactivates Ara-C by dephosphorylation
, has been shown to predict ara-C sensitivity.29
It also plays an active role in the activation and dephosphorylation
of glycogen synthetase.
(12) This Ulk1 dephosphorylation
also triggers Ulk1 translocation to pre-autophagosomal membranes.
of tau by protein phosphatase 5: impairment in Alzheimer's disease.
The activity of these signaling pathways is regulated through phosphorylation and by an opposing process of dephosphorylation
mediated by phosphatases.