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 (DNase) [de-ok″sĭ-ri″bo-nu´kle-ās]
an enzyme that catalyzes the hydrolysis (depolymerization) of deoxyribonucleic acid (DNA).

de·ox·y·ri·bo·nu·cle·ase (DNAse, DNAase, DNase),

Any enzyme (phosphodiesterase) hydrolyzing phosphodiester bonds in DNA.
See also: endonuclease, nuclease.


(dē-ŏk′sē-rī′bō-no͞o′klē-ās′, -āz′, -nyo͞o′-)


A gene on chromosome 14q11.2 that encodes a major apurinic/apyrimidinic (AP) endoDNAase, which is involved in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, and in the redox regulation of transcriptional factors.


(DNase) (de-oks'ē-rī'bō-nū'klē-ās)
Any enzyme (phosphodiesterase) hydrolyzing phosphodiester bonds in DNA.
See also: endonuclease, nuclease


An enzyme that cuts DNA strands by breaking PHOSPHODIESTER BONDS.

deoxyribonuclease (DNAse)

References in periodicals archive ?
Androgen Ablation Leads to an Upregulation and Intranuclear Accumulation of Deoxyribonuclease I in Rat Prostate Epithelial Cells Paralleling Their Apoptotic Elimination J.
Measurement of deoxyribonuclease I activity in human tissues and body fluids by a single radial enzyme-diffusion method.
An abrupt elevation of the serum deoxyribonuclease I (DNase I) activity in acute myocardial infarction [Abstract].
Human genetically polymorphic deoxyribonuclease: purification, characterization, and multiplicity of urine deoxyribonuclease I.
Human urine deoxyribonuclease II (DNase II) isozymes: a novel immuncaffinity purification, biochemical multiplicity, genetic heterogeneity, and broad distribution among tissues and body fluids.
[34.] Shastina BB (2004) Deoxyribonuclease sperm of the sea urchin.
[35.] Lazarus RA, Wagener JS (2007) Recombinant Human Deoxyribonuclease I".
[39.] Taper HS (2008) Altered deoxyribonuclease activity in cancer cells and its role in nontoxic adjuvant cancer therapy with mixed vitamins C and K3.

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