deoxypyridinoline


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deoxypyridinoline

Bone disease A crosslink of type I collagen present in bone which is excreted unmetabolized in urine and is a specific marker of bone resorption, and ↑ in Pts with osteoporosis. See Osteoporosis, Pyrilinks-D®.

deoxypyridinoline

(dē-ŏk″sē-pĭ-rĭ-dĭn′ō-lēn, -lĭn),

Dpd

A component of the structural matrix of bone, principally found in type 1 collagen as a structural cross link. It provides tensile strength to bone.

When bone resorption exceeds bone rebuilding (for example, in osteoporosis), Dpd is released into the circulation and excreted unchanged in the urine. The detection of elevated levels of Dpd in a concentrated urine specimen is used as a marker of ongoing bone loss in osteoporosis. Reduced levels of Dpd are an indicator of the effectiveness of therapies that reduce bone resorption (e.g., bisphosphonates).

The Dpd urine test is performed by obtaining the first urine voided by a patient on awakening—this ensures that the specimen will be maximally concentrated. The level of Dpd obtained is expressed in nmol of Dpd/mmol of urinary creatinine.

References in periodicals archive ?
Bone gla-protein and deoxypyridinoline crosslinks ELISA kits were purchased from Xinyu Biological Engineering Co.
Serum B2-microglubulin concentration correlates with urinary concentrations of type | collagen cross-linked N-telopeptides and deoxypyridinoline in rheumatoid arthritis.
We measured the following biochemical markers related to bone metabolism: PTH, osteocalcin, and bone alkaline phosphatase (bALP) in serum; and deoxypyridinoline (U-DPD) and calcium in urine.
Evans, "Standardization of pyridiniumcross links, pyridinoline and deoxypyridinoline, for use as biochemical markers of collagen degradation," Clinical Chemistry, vol.
Serum concentrations of type I collagen C-terminal telopeptide (CTX-I) and cartilage oligomeric matrix protein (COMP) and urinary concentrations of deoxypyridinoline (DPD) were measured, and disease severity was assessed.
(17) reported that among markers of bone turnover, BALP osteocalcin, and CTx and NTx (N-and C-terminal collagen cross-links) levels were within normal limits whereas urinary deoxypyridinoline levels were increased.
Thyroid hormone stimulates bone resorption and increases markers of bone resorption, including C-telopeptide, N-telopeptide, and deoxypyridinoline. Parathyroid hormone (PTH) is decreased in nonparathyroid hypercalcemia.
They found that osteocalcin--a bone protein that is thought to facilitate bone formation--was unchanged, while the marker for bone loss (deoxypyridinoline, or Dpd) decreased by 18%.
Though mea-surement of total urinary hydroxylvsyl pyridinoline ("Pyridinoline") and lysyl pyridinoline ("Deoxypyridinoline") crosslinks after hydrolysis by HPLC could not be done because of lack of facility in Bangladesh, fulfillment of clinical criteria in both siblings are strongly in favor of our diagnosis.
Furthermore, urinary cadmium was negatively associated with parathyroid hormone (a bone metabolism hormone) and positively associated with urinary deoxypyridinoline (a bone resorption marker).
Differences in levels of urinary markers such as pyridinoline and deoxypyridinoline between the treatment and placebo groups suggested a decrease in the rate of bone resorption.
For example, in one unpublished study by van Daele and colleagues, the level of deoxypyridinoline correlated with relative fracture risk.