Bone gla-protein and deoxypyridinoline
crosslinks ELISA kits were purchased from Xinyu Biological Engineering Co.
Serum B2-microglubulin concentration correlates with urinary concentrations of type | collagen cross-linked N-telopeptides and deoxypyridinoline
in rheumatoid arthritis.
We measured the following biochemical markers related to bone metabolism: PTH, osteocalcin, and bone alkaline phosphatase (bALP) in serum; and deoxypyridinoline
(U-DPD) and calcium in urine.
Evans, "Standardization of pyridiniumcross links, pyridinoline and deoxypyridinoline
, for use as biochemical markers of collagen degradation," Clinical Chemistry, vol.
Serum concentrations of type I collagen C-terminal telopeptide (CTX-I) and cartilage oligomeric matrix protein (COMP) and urinary concentrations of deoxypyridinoline
(DPD) were measured, and disease severity was assessed.
(17) reported that among markers of bone turnover, BALP osteocalcin, and CTx and NTx (N-and C-terminal collagen cross-links) levels were within normal limits whereas urinary deoxypyridinoline
levels were increased.
Thyroid hormone stimulates bone resorption and increases markers of bone resorption, including C-telopeptide, N-telopeptide, and deoxypyridinoline
. Parathyroid hormone (PTH) is decreased in nonparathyroid hypercalcemia.
They found that osteocalcin--a bone protein that is thought to facilitate bone formation--was unchanged, while the marker for bone loss (deoxypyridinoline
, or Dpd) decreased by 18%.
Though mea-surement of total urinary hydroxylvsyl pyridinoline ("Pyridinoline") and lysyl pyridinoline ("Deoxypyridinoline
") crosslinks after hydrolysis by HPLC could not be done because of lack of facility in Bangladesh, fulfillment of clinical criteria in both siblings are strongly in favor of our diagnosis.
Furthermore, urinary cadmium was negatively associated with parathyroid hormone (a bone metabolism hormone) and positively associated with urinary deoxypyridinoline
(a bone resorption marker).
Differences in levels of urinary markers such as pyridinoline and deoxypyridinoline
between the treatment and placebo groups suggested a decrease in the rate of bone resorption.
For example, in one unpublished study by van Daele and colleagues, the level of deoxypyridinoline
correlated with relative fracture risk.