2-deoxy-d-glucose

(redirected from Deoxyglucose)

2-deoxy-d-glucose

 [de-ok´sĭ-gloo´kōs]
an antimetabolite of glucose with antiviral activity; it acts by inhibiting the glycosylation of glycoproteins and glycolipids; it has been investigated for treatment of herpesvirus infections.
References in periodicals archive ?
Positron emission tomography of a human prostate cancer xenograft: association of changes in deoxyglucose accumulation with other measures of outcome following androgen withdrawal.
According to these criteria, patients had presumed sarcoidosis if they had at least two of the following four criteria: typical changes on a chest radiograph or chest computed tomography (CT), predominantly CD4 lymphocytosis on bronchoalveolar lavage (BAL) fluid analysis, elevated serum angiotensin converting enzyme (ACE) levels, or a high gallium or 18Flabelled deoxyglucose positron emission tomography (18FDG-PET) uptake.
Initially glucose was added, followed by oligomycin and 2 deoxyglucose to inhibit glycolytic activities, thus leaving ECAR due to cellular nonglycolytic activities.
Radda, "Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart," Cardiovascular Research, vol.
As a fluorescent deoxyglucose analogue, 2-NBDG is transported into cells and enters the glycolytic pathway in HepG2 cells (Wang et al., 2011), and vascular muscle cells (Ye et al., 2008)..
The PET imaging performed to demonstrate deep infection showed an intense and diffuse accumulation of the deoxyglucose labeled with fluorine 18 (FDG) in the prostate (Fig.
Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patients.
Type-II collagenase and tritiated deoxyglucose (2-deoxy-D-[2,6-[sup.3]H] glucose) were procured from Worthington (New Jersey, USA) and Perkin Elmer (Massachusetts, USA), respectively.
We measured glucose uptake (2-6 deoxyglucose uptake) and mRNA content of proteins (GLUT-4; IRS-1) involved in insulin signaling in soleus muscle.
Inflammatory cells have an increased positive expression of glucose transporters and growth factors, which affect the affinity of these transporters for deoxyglucose. The net result is seen as a high accumulation of F-18 FDG in areas of infection because it is carried into cells by the glucose transporters.
(1977) The 14C deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat.
Deoxyglucose (+DOG) did not mimic this response indicating the requirement for a metabolizable carbohydrate source to achieve measurable leucine oxidation.