Dentin Sialophosphoprotein | definition of Dentin Sialophosphoprotein by Medical dictionary
DSPP (redirected from Dentin Sialophosphoprotein)
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DSPP A gene on chromosome 4q21.3 that encodes one of the two main proteins of the dentin extracellular matrix, which is secreted as a preproprotein by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be
involved in the biomineralisation process of dentin.
DSPP mutations are associated with dentinogenesis imperfecta-1, which in some patients is combined with autosomal dominant form of deafness.
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References in periodicals archive
The gene expression of dentin sialophosphoprotein
(DSPP), alkaline phosphatase (ALP) and osteocalcin (OCN) was analyzed using fluorescent quantitative reverse transcriptase-polymerase chain reaction (FQ-PCR).
The expression levels of dentin sialophosphoprotein
(DSPP), dentin matrix protein-1 (DMP-1), runt-related transcription factor-2 (Runx2), and osteocalcin (OCN) mRNA were determined by SYBR green real-time reverse transcription-PCR (RT-PCR) as previously described [22-24].
Target gene Primer sequences Alkaline phosphatase (ALP) For-5'-CTTGACCTCCTCGGAAGACACTC-3' Rev-5'-CGCCCACCACCTTGTAGCC-3' Bone sialophosphoprotein (BSP) For-5'-TACCGAGCCTATGAAGATGA-3' Rev-5'-CTTCCTGAGTTGAACTTCGA-3' Osteopontin (OPN) For-5'-GTGGGAAGGACAGTTATGAA-3' Rev-5'-CTGACTTTGGAAAGTTCCTG-3' Osteonectin (ONT) For-5'-CTGTTGCCTGTCTCTAAACC-3' Rev-5'-CACCATCATCAA ATTCTCCT-3' Osteocalcin (OCN) For-5'-TGAGTCCTGAGCAGCAG-3' Rev-5'-TCTCTTCACTACCTCGCT-3' Dentin matrix protein 1 (DMP1) For-5'-GACTCTCAAGAAGACAGCAA-3' Rev-5'-GACTCACTCACCACCTCT-3' Dentin sialophosphoprotein
For-5'-CAGTACAGGATGAGTTAAATGCCAGTG-3' (DSPP) Rev-5'-CCATTCCCTTCTCCCTTGTGACC-3' GAPDH For-5'-GTATGACAACAGCCTCAAGAT-3' Rev-5'-CCTTCCACGATACCAAAGTT-3'