dense granule

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dense granule

Cardiology
A specialised spherical storage and secretory vesicle in platelets which contains ADP, ATP, ionised calcium, pyrophosphate and serotonin. Reduced-platelet dense-granule secretion is associated with marked protection against arterial thrombosis, inflammation, and neointimal hyperplasia after vascular injury in a mouse model.

Pathology
Dense-core granules, see there.

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References in periodicals archive ?

When released, alpha granules, dense granules, and lysosomes secrete their contents to assist in the adhesion of segregation of platelets.

Diagnostic considerations with inherited platelet disorder testing: This month's CE is comprised of two articles

Vaccination studies in mice have focused on the selection of protective antigens and the most promising experimental vaccines now combine proteins from micronemes, dense granules, and rhoptry organelles that are secreted by the parasite during active invasion of the host cell (7).

Evaluation of Immune Responses Induced by GRA7and ROP2 Genes by DNA Vaccine Cocktails Against Acute Toxoplasmosis in BALB/c Mice

In the resting state, platelets have a smooth discoid shape and contain cytoplasmic organelles, cytoskeletal elements, platelet-specific alpha and dense granules and an invaginating open-cannalicular phospholipid membrane.

Inherited bleeding disorders. (CME)

STEM analysis of thrombocytes from control group showed the presence of microtubules and cell organelles, especially alpha granules and dense granules (Figures 6(g) and 7(g)).

The Effect of PEI and PVP-Stabilized Gold Nanoparticles on Equine Platelets Activation: Potential Application in Equine Regenerative Medicine

Platelet activation causes the release of different granule populations such as [alpha]-granules and dense granules; these secretions boost platelet activation and intracellular signaling.

Schisandra chinensis and Morus alba Synergistically Inhibit In Vivo Thrombus Formation and Platelet Aggregation by Impairing the Glycoprotein VI Pathway

caninum exhibits three morphologically distinct secretory organelles named micronemes, rhoptries, and dense granules [4].

First Characterization of the Neospora caninum Dense Granule Protein GRA9

By contrast, gamma-irradiated tachyzoites group showed vacuolization in their cytoplasm with the substantial reduction in the number of dense granules and the blur of some organelles.

Ultrastructure of Toxoplasma gondii RH Tachyzoites Attenuated by Gamma Radiation and Histopathological Alterations in Mice Vaccinated with it

Juxtaligamental cell cytoplasm contains numerous electron dense granules that are believed to release substances that affect the interaction between the extracellular matrix molecules and cause rapid changes in the mechanical properties of the connective tissue in response to stimuli from the nervous system (Wilkie and Emson, 1987; Wilkie.

Autotomy of the visceral mass in the feather star himeroinetra robustipinna (crinoidea, comatulida)

Resting platelets express 80,000-100,000 molecules of aIIbb3 on their surface.9 In addition to the surface receptors, 20,000-40,000 molecules of aIIbb3 are also present in the a-granules, dense granules and on the membranes of open canalicular system of the platelets.

Platelet receptors: An instrumental of platelet physiology

"Our products are dense granules impregnated with flavor," says company founder Mark Weiser.

Pavlov's cats: baiting and chumming lure hungry catfish

Aplysia juliana had large pitted electron dense granules in cells adjacent to rhodoplast digestive cells (Figure 1(b)).

Role of the digestive gland in ink production in four species of sea hares: an ultrastructural comparison