dense granule

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dense granule

Cardiology
A specialised spherical storage and secretory vesicle in platelets which contains ADP, ATP, ionised calcium, pyrophosphate and serotonin. Reduced-platelet dense-granule secretion is associated with marked protection against arterial thrombosis, inflammation, and neointimal hyperplasia after vascular injury in a mouse model.

Pathology
Dense-core granules, see there.
References in periodicals archive ?
When released, alpha granules, dense granules, and lysosomes secrete their contents to assist in the adhesion of segregation of platelets.
Vaccination studies in mice have focused on the selection of protective antigens and the most promising experimental vaccines now combine proteins from micronemes, dense granules, and rhoptry organelles that are secreted by the parasite during active invasion of the host cell (7).
In the resting state, platelets have a smooth discoid shape and contain cytoplasmic organelles, cytoskeletal elements, platelet-specific alpha and dense granules and an invaginating open-cannalicular phospholipid membrane.
STEM analysis of thrombocytes from control group showed the presence of microtubules and cell organelles, especially alpha granules and dense granules (Figures 6(g) and 7(g)).
Platelet activation causes the release of different granule populations such as [alpha]-granules and dense granules; these secretions boost platelet activation and intracellular signaling.
caninum exhibits three morphologically distinct secretory organelles named micronemes, rhoptries, and dense granules [4].
By contrast, gamma-irradiated tachyzoites group showed vacuolization in their cytoplasm with the substantial reduction in the number of dense granules and the blur of some organelles.
Juxtaligamental cell cytoplasm contains numerous electron dense granules that are believed to release substances that affect the interaction between the extracellular matrix molecules and cause rapid changes in the mechanical properties of the connective tissue in response to stimuli from the nervous system (Wilkie and Emson, 1987; Wilkie.
Resting platelets express 80,000-100,000 molecules of aIIbb3 on their surface.9 In addition to the surface receptors, 20,000-40,000 molecules of aIIbb3 are also present in the a-granules, dense granules and on the membranes of open canalicular system of the platelets.
"Our products are dense granules impregnated with flavor," says company founder Mark Weiser.
Aplysia juliana had large pitted electron dense granules in cells adjacent to rhodoplast digestive cells (Figure 1(b)).