Identifiable causes of SSNHL include viral infections, vascular events, cochlear hydrops, head trauma, tumors (eg, vestibular schwannoma), and
demyelinating disorders. Bilateral SSNHL can be seen in autoimmune diseases and rarely can be caused by medications, such as aminoglycosides or certain chemotherapy medications.
The therapeutic potential of antisense therapies targeting glial cells in rare and fatal
demyelinating disorders, including Alexander disease, multiple sclerosis, traumatic injuries and stroke.
While patients having meningitis or encephalitis with encephalopathy, acquired
demyelinating disorder other than ADEM like multiple sclerosis, transverse myelitis, optic neuritis and neuromyelitis optica or any inherited
demyelinating disorders like Leukodystrophies were excluded.
Heat sensitivity (Uhthoff's phenomenon) is a characteristic of MS and other
demyelinating disorders, and it is defined as stereotypical and reversible neurological decline, secondary to hyperthermia.
The MSC2 phenotype, with its enhanced anti-inflammatory function, has therapeutic potential against
demyelinating disorders (e.g., optic neuritis, multiple sclerosis, and Krabbe disease), diabetic neuropathy, and inflammatory disorders (e.g., rheumatoid arthritis and Crohn's disease).
International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system
demyelinating disorders: revisions to the 2007 definitions.
The company said the multiple preclinical studies of CNM-Au8 demonstrated the remyelination effects as a potential treatment for multiple sclerosis and other
demyelinating disorders. CNM-Au8 is a novel orally administered gold nanocrystal suspension.
We strongly believe that larger HLAgenotyping studies regarding early-onset
demyelinating disorders are necessary.
Although NBS is relatively uncommon, being potentially treatable, neurologists need to consider it in the differential diagnosis of inflammatory infective, or
demyelinating disorders (6).
Krupp et al.10 reported that neuromyelitis optica is one of the CNS inflammatory
demyelinating disorders presenting in children which is suggestive of multiple sclerosis.10
Patients should avoid factors that may trigger the relapse of inflammatory
demyelinating disorders of the nervous system,[sup][51],[77] such as hot bath, exposure to high temperature under sunshine, cigarette smoking, and vaccination.
Multifocal or extensive demyelinating changes are also found, which suggests that anti-NMDAR encephalitis patients may develop episodes of
demyelinating disorders simultaneously or separately [74].
