Demyelinating disorders

Demyelinating disorders

A group of diseases characterized by the breakdown of myelin, the fatty sheath surrounding and insulating nerve fibers. This breakdown interferes with nerve function, and can result in paralysis. Multiple sclerosis is a demyelinating disorder.
Mentioned in: Transverse Myelitis
References in periodicals archive ?
The company said the multiple preclinical studies of CNM-Au8 demonstrated the remyelination effects as a potential treatment for multiple sclerosis and other demyelinating disorders.
Although NBS is relatively uncommon, being potentially treatable, neurologists need to consider it in the differential diagnosis of inflammatory infective, or demyelinating disorders (6).
10 reported that neuromyelitis optica is one of the CNS inflammatory demyelinating disorders presenting in children which is suggestive of multiple sclerosis.
Patients should avoid factors that may trigger the relapse of inflammatory demyelinating disorders of the nervous system,[sup][51],[77] such as hot bath, exposure to high temperature under sunshine, cigarette smoking, and vaccination.
Figure 2 (A) demonstrates on MR spectroscopy elevated choline peak (arrow) indicating myelin breakdown products, lactate doublet (arrowhead) and myo-inositol peak (asterisk) which can be seen in demyelinating disorders such as ADEM; Axial FLAIR images during relapses at four months (B) and two years (C) after the initial diagnosis of ADEM showing new demyelinating lesions during each relapse.
She completed pediatrics training at McMaster University and pediatric neurology training at SUNY Buffalo, where she developed and co-directed the Pediatric MS and Demyelinating Disorders Center of Excellence.
Normal nerve function is lost in demyelinating disorders, such as MS and the rare, fatal, childhood disease, Krabbe's disease.
Germany) bring together 21 chapters by neurologists and other medical specialists from North America, Europe, and Israel who discuss advances in the diagnosis and treatment of multiple sclerosis and demyelinating disorders, including clinically isolated syndromes, pediatric MS, transverse myelitis, acute disseminated encephalomyelitis, and neuromyelitis optica.
With Promise: 2010 funding, the Society established the first-of-its-kind network of six Pediatric MS Centers of Excellence to provide comprehensive evaluation and care to children with MS and related central nervous system demyelinating disorders.
There were no cases of tuberculosis, other opportunistic infections, or demyelinating disorders for any of the TNF antagonists during the placebo-controlled portion of the clinical trials.
This suggested myelin-repairing property of prolactin is highly relevant to the development of potential therapies, not only for demyelinating disorders such as multiple sclerosis but also for schizophrenia.
The article then uses an empirical study of demyelinating disorders and their handling under the program to show how courts deal with causation where there is general uncertainty as to the causal link between the vaccine and the injury.