In humans, demodicosis is caused by two species of mites: Demodex folliculorum
Bu turler Demodex folliculorum
ve Demodex brevis'tir.
and Demodex brevis are two species of translucent, spindle-shaped ectoparasites that live in the hair follicles and sebaceous glands of human skin.
Higher levels of Demodex folliculorum
and Staphylococcus epidermis also have been consistently found on the skin of rosacea patients, compared with healthy subjects, though it is unclear what role these pathogens play in the development of rosacea.
Demodecosis is a skin disease caused by parasitic Demodex mites, principally Demodex folliculorum
longus which live in the glands of hair follicles and Demodex folliculorum
brevis which reside in sebaceous (oil) glands connected to hair follicles.
Caption: Demodex folliculorum
mites, shown in false color, live on human skin, where they've been hitching rides for thousands of years.
Though the etiology of rosacea is not fully understood, immune system dysfunction, inflammatory reaction to cutaneous microorganisms, Demodex folliculorum
infestation, environmental factors like sunlight, and vascular anomalies have been implicated in its pathogenesis.
The role of Demodex folliculorum
, commensal mite of the pilosebaceous follicle, has long been debated; it would promote inflammation by mechanical blockage of follicles.
A preliminary note on Demodex folliculorum
Simon (1842), as a possible vector of leprosy.
Normal skin Demodex folliculorum
(a head sebaceous follicle lumen mite), usually located at the upper part of the infundibulum of the follicle , has been indirectly involved in rosacea, although a possible causal correlation has not been established up to this day.