CCR5

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CCR5

A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES, and transduces a signal by increasing the intracellular calcium ion level. CCR5 may play a role in the control of granulocytic lineage proliferation or differentiation, and is an important co-receptor for macrophage-tropic viruses (e.g., HIV-1) entering host cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

CCR5

A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed.
Mentioned in: AIDS
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
They found that people who have two copies of the Delta 32 mutation are about 20% less likely to reach age 76 compared with people who have one or no copies.
class="MsoNormalThere is at least one reported case of an individual who got a transplant from a delta 32 donor but later rebounded with the X4 virus.
Studies conducted in mouse models of WNV infection clearly demonstrate that in the presence of the delta 32 mutation, far fewer of these lymphocytes are present in brain tissue, reflecting inhibition of the cell-mediated host immune response to the viral pathogen, the neurologist explained.
Research by geneticist Stephen O'Brien has traced Crohn's Delta 32 mutation back hundreds of years to towns like Eyam, where the defensive genetic mutation held off the black death in much the same way it now protects Crohn from HIV.
Finnish medical technology company Instrumentarium said today (3 October) that its subsidiary Instrumentarium Imaging had received clearance from the the US Food and Drug Administration (FDA) to market the Delta 32 and Delta 32 TACT diagnostic digital breast imaging systems in the USA.
Scientists found families of survivors from Eyam, in the Peak District, have a special gene, Delta 32.
Subsequent research has shown that some LTNPs are heterozygous for the CCR5 mutation, called "CCR5 delta 32," i.e.
The donor -- who was unrelated -- had a genetic mutation known as 'CCR5 delta 32', which confers resistance to HIV.
16 on Black Elk Energy Offshore Operations LLC's platform located at West Delta 32 Block, in the Gulf of Mexico 17 miles southeast of Grand Isle, LA.
Huetter revealed that some people carry a genetic mutation called Delta 32 that apparently makes them resistant to HIV infection.
Researchers at the University of California in San Francisco have created modified white cells with HIV resistance by editing genomes of stem cells which replicates the CCR5 delta 32 mutation found in small number of people in Europe.
It replicates the known genetic factor called CCR5 delta 32 that prevents HIV to attach itself with immune cells and render it unable to replicate in the body.