delayed graft function


Also found in: Acronyms.

delayed graft function

A form of acute renal failure resulting in post-transplantation oliguria, increased allograft immunogenicity and risk of acute rejection episodes, and decreased long-term survival, which are linked to the donor and prerenal, renal or postrenal transplant factors related to the recipient.
 
Pathogenesis
Delayed graft function is linked to ischaemia and reinstitution of blood flow in ischaemically damaged kidneys after hypothermic preservation.
References in periodicals archive ?
Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis.
Predictive score model for delayed graft function based on easily available variables before kidney donation after cardiac death.
HLA: human leukocyte antigen; DGF: delayed graft function; POD: post-operative days; PCR: protein/creatinine ratio.
LRD, LURD, p-value (n = 28) (n = 42) Primary non-function 0 2 (4.7) 0.301 Delayed graft function 0 2 (4.7) 0.301 Surgical 5 (17.8) 18 (42.8) 0.005 complication RAS 1 (3.5) 4 (9.5) 0.440 Wound infection 0 3 (7.1) 0.540 Obstruction/leaks 0 5 (11.9) 0.095 Recurrent UTI 4 (14.2) 5 (11.9) 0.356 Deep vein 0 1 (2.3) 0.468 thrombosis Viral infection 16 (57.1) 19 (45.2) 0.747 CMV 4 (14.2) 7 (16.6) 0.111 EBV 1 (3.5) 1 (2.3) 0.723 BKV 4 (14.2) 5 (11.9) 0.542 Warts virus 3 (10.7) 3 (7.1) 0.523 Hepatitis C virus 0 2 (4.7) 0.124 Herpes virus 4 (14.2) 1 (2.3) 0.054 Fungal infection 0 3 (7.1) 0.202 Early 0 5 (11.9) 0.230 nephrectomy Malignancy 1 (3.5) 2 (4.7) 0.896 Hypertension 15 (53.3) 31 (73.8) 0.147 Acute rejection 5 (17.8) 9 (21.4) 0.747 Datapresentedas n (%).
Delayed graft function occurs in 10-31% cases in patients with DKT [16, 18-22, 24, 32, 34].
The association of urinary tract infections with delayed graft function was shown earlier by some authors [50].
In addition, transplanted kidney undergoes various stressors including warm ischemia, cold ischemia, and delayed graft function and, later on, rejection and exposure to calcineurin inhibitors.
Delayed graft function rate (%)###6.3%###6.8%###70 years) does not affect graft survival in the medium term.
Serum neutrophil gelatinase-associated lipocalin and interleukin-18 as predictive biomarkers for delayed graft function after kidney transplantation.
van Es, "Calcium levels as a risk factor for delayed graft function," Transplantation, vol.
This event can lead to immediate and long-term graft dysfunction, such as allograft rejection, delayed graft function (DGF), and even primary nonfunction (PNF) [1].
Infections, like urinary and cytomegalovirus infections, and delayed graft function were the most frequent complications.
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