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ASSETA trial designed to determine tPA’s efficacy in reducing post-acute myocardial infarction mortality.
Conclusion At 1 month, 7% of rt-PA patients and 10% of placebo patients had died, which translates as a 26% reduction in mortality with rt-PA; at 6 months, mortality was 10% with rt-PA and 13% with placebo, a 21% decrease in mortality; tPA reduced mortality, but not morbidity (rates of recurrent infarction, angina, or heart failure), if given within 5 hours of onset of symptoms; alteplase reduced mortality by 33% over the placebo controls in those age 66 to 75, and by 14% in those under age 65.
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ASSETCardiology A clinical trial–Anglo-Scandinavian Study of Early Thrombolysis that compared the mortality in acute MI Pts randomized to tPA or placebo. See Acute myocardial infarction, tPA. Cf GISSI, TIMI-2.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.