defective interfering particle

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de·fec·tive in·ter·fer·ing par·ti·cle

an incomplete virus that is unable to replicate and interferes with replication of an infectious virus.
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Pathogenesis and virulence of flaviviruses are influenced in vivo by several virus- and host-dependent factors, including the role of defective interfering particles, viral receptors, neurovirulence, immune-response (e.g., antibody-dependent enhancement), and host resistance genes (8).
Cell monolayers were infected with a multiplicity of infection of 0.1 virus per cell to avoid the possible appearance of defective interfering particles characteristic of the high-multiplicity infections with VSV.