Zhang et al., "The Fas-associated death domain
protein is required in apoptosis and TLR-induced proliferative responses in B cells," Journal of Immunology, vol.
Silencing of fas-associated death domain
protects mice from septic lung inflammation and apoptosis.
DR4 and DR5 are type I transmembrane proteins that contain a death domain
in their cytoplasmic domain that can bind to other death domains
The Cterminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain
(FADD) recruitment and can regulate agonist-specific mechanism of receptor activation.
An interesting variation in the sea urchin NLR genes is the presence of an N-terminal Death domain
on most of the gene family members.
Genetics Institute, LLC (Cambridge, MA) has patented TNF receptor death domain
("TNF-R1-DD") ligand proteins.
DR3, also known as APO-3, TRAMP, LARD, and WSL-1, is a member of the tumor necrosis factor receptor superfamily (TNFRSF) with a typical death domain
that consists of an approximately 60-amino-acid globular bundle of 6 conserved [alpha] helices found in the cytoplasmic region.
Siva-1 consists of several distinct domains: an N-terminal region, a putative amphipathic helical (SAH) region, a death domain
homology region (DDHR), and a C-terminal cysteine-rich region that includes a B-BOX domain and a zinc-finger-like domain (2,3).
Led by Stefan Riedl, Ph.D., the study pointed out how protein-protein interactions between Fas receptor and Fas-associated death domain
protein (FADD) mechanistically control DISC formation.
Upon binding their cognate ligands, the intracellular domains of death receptors recruit adapter molecules such as Fas-associated death domain
(FADD) and TNF receptor-associated death domain
(TRADD) (Daniel et al., 2001), which in turn recruit procaspase-8, an initiator caspase.
(Rockville, MD) and University of Michigan (Ann Arbor, MI) has patented Death Domain
Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family.
TNFSF receptors can be divided into two groups depending on the presence or absence of the intracellular death domain