Amanita phalloides

Am·a·ni·ta phal·loi·'des

a species of fungus containing poisonous elements, including phalloidin and amanitin, which cause gastroenteritis, hepatic necrosis, and renal necrosis.

Synonym(s): deadly agaric

A mushroom which, along with related species—A bisporigera, A verna, A virosa—is the most common cause of fatal mushroom poisonings
Mechanism The major toxins are amanatins, a series of closely related heat-stable cyclic octapeptides, which inhibit RNA polymerase in liver cells
Management Symptomatic-rehydration, IV glucose, instillation of 100 g of activated charcoal per os, mannitol to prevent oliguria; 50% of late-treated patients die

Amanita phalloides

Toxicology A mushroom which, with related species–A bisporigera, A verna, A virosa are the most common cause of fatal mushroom poisonings Clinical After a 12-hr latency, N&V, abdominal colic, severe watery diarrhea; this is followed by a 24-hr latency period, then–if the amount ingested was significant—by fatal hepatitis and renal failure Management Symptomatic-rehydration, IV glucose, instillation of 100 g of activated charcoal per os, mannitol to prevent oliguria; 50% of late-treated Pts die. See Poisonous mushroom.

Am·a·ni·ta phal·loi·des

(am'ă-nī'tă fă-loy'dēz)

A species of mushroom containing poisonous principles (including phalloidin and amanitin) that cause gastroenteritis, hepatic necrosis, and renal necrosis.